Listeria monocytogenes Meningitis in a Female Patient with Primary Mediastinal (Thymic) Large B-Cell Lymphoma: A Case Report

Listeriosis with severe clinical manifestations in the form of bacteraemia, sepsis, and meningitis/meningoencephalitis is a rare but a challenging issue of supportive care in oncohematology. Early diagnosis of listeriosis, as well as any other infection, is hampered by severe general manifestations of a malignant lymphoproliferative disorder or tumor complications and its treatment. In patients with pronounced decreased drug-induced immunity listeriosis is usually characterized as a rapidly developing and, as a rule, severe disease with high immediate mortality. The present article offers a case report of severe listeria infection in a female patient admitted to the intensive care unit for the treatment of primary mediastinal (thymic) large B-cell lymphoma with a large tumor mass in anterior mediastinum complicated by mediastinal and superior vena cava compression syndromes.

• A.M. Pronina NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478 ; ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478
• S.V. Zhuravleva NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478 ; ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478
• G.S. Yunaev NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478 ; ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478
• I.Z. Zavodnova NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478 ; ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478
• Ildar Anvarovich Kurmukov AS Loginov Moscow Clinical Scientific Center, 89 Entuziastov sh., Moscow, Russian Federation, 111123 ; ГБУЗ «Московский клинический научный центр им. А.С. Логинова ДЗМ», ш. Энтузиастов, д. 86, Москва, Российская Федерация, 111123

1. Hernandez-Milian A, Payeras-Cifre A. What Is New in Listeriosis? Biomed Res Int. 2014;2014:358051. doi: 10.1155/2014/358051. DOI: https://doi.org/10.1155/2014/358051
2. Pagliano P, Arslan F, Ascione T. Epidemiology and treatment of the commonest form of listeriosis: meningitis and bacteraemia. Le Infezioni in Medicina. 2017;25(3):210–6.
3. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA. 1993;270(24):2957–63. doi: 10.1001/jama.1993.03510240069035. DOI: https://doi.org/10.1001/jama.1993.03510240069035
4. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13(10):818–29. DOI: https://doi.org/10.1097/00003246-198510000-00009
5. Freitag NE, Port GC, Miner MD. Listeria monocytogenes – from saprophyte to intracellular pathogen. Nat Rev Microbiol. 2009;7(9):623–8. doi: 10.1038/nrmicro2171. DOI: https://doi.org/10.1038/nrmicro2171
6. Курмуков И.А. Бактериальные и грибковые инфекционные осложнения ближайшего и раннего периода трансплантации. Трансплантология. 2010;2:5–9. doi: 10.23873/2074-0506-2010-0-2-5-9.[Kurmukov IA. Bacterial and fungal infectious complications in the immediate and early periods of transplantation. Transplantologiya. 2010;2:5–9. doi: 10.23873/2074-0506-2010-0-2-5-9. (In Russ)]
7. Jensen AK, Simonsen J, Ethelberg S. Use of Proton Pump Inhibitors and the Risk of Listeriosis: A Nationwide Registry-based Case-Control Study. Clin Infect Dis. 2017;64(7):845–51. doi: 10.1093/cid/ciw860. DOI: https://doi.org/10.1093/cid/ciw860
8. Yildiz O, Aygen B, Esel D, et al. Sepsis and Meningitis Due to Listeria Monocytogenes. Yonsei Med J. 2007;48(3):433–9. doi: 10.3349/ymj.2007.48.3.43 DOI: https://doi.org/10.3349/ymj.2007.48.3.433
9. Обухова О.А., Курмуков И.А., Боровкова Н.Б. и др. Диагностическая чувствительность биомаркеров сепсиса при тяжелой инфекции у онкологических больных, получивших противоопухолевое лечение. Онкогинекология. 2018:26(2):54–61.[Obukhova OA, Kurmukov IA, Borovkova NB, et al. Diagnostic sensitivity of biomarkers of sepsis resulting from severe infection in cancer patients who underwent antitumor treatment. Onkoginekologiya. 2018:26(2):54–61. (In Russ)] DOI: https://doi.org/10.52313/22278710_2018_2_54
10. Курмуков И.А., Кашия Ш.Р., Обухова О.А. и др. Первичная диагностика сепсиса у пациентов, получающих лекарственное лечение по поводу онкологического заболевания: сравнение критериев SIRS и SOFA. Трансляционная медицина. 2017;4(2):46–51. doi: 10.18705/2311-4495-2017-4-2-46-51. [Kurmukov IA, Kashiya ShR, Obukhova OA, et al. Primary diagnosis of sepsis in patients receiving medical treatment for oncological disease: comparison of SIRS and SOFA criteria. Translational Medicine. 2017;4(2):46–51. doi: 10.18705/2311-4495-2017-4-2-46-51. (In Russ)] DOI: https://doi.org/10.18705/2311-4495-2017-4-2-46-51
11. van Veen KEB, Brouwer MC, van der Ende A, et al. Bacterial Meningitis in Patients using Immunosuppressive Medication: a Population-based Prospective Nationwide Study. J Neuroimmune Pharmacol. 2017;12(2):213–8. doi: 10.1007/s11481-016-9705-6. DOI: https://doi.org/10.1007/s11481-016-9705-6
12. Hof H. An update on the medical management of listeriosis. Expert Opin Pharmacother. 2004;5(8):1727–35. doi: 10.1517/14656566.5.8.1727. DOI: https://doi.org/10.1517/14656566.5.8.1727