Role of tyrosine-kinase inhibitor selectivity in development of adverse effects during treatment of chronic myeloid leukemia

This review focuses on association between the selectivity of Bcr-Abl kinase inhibitors and the spectrum of their adverse effects during treatment of patients with chronic myeloid leukemia. The data on the structure and natural biochemical functions of the well-known adverse targets for inhibitors of Bcr-Abl kinases, including BRAF, FMS, EGFR, PDGFR, PYK2, TIE2, and VEGFR1/2/3 are summarized, and the potential association between their off-target inhibition and adverse effects of tyrosine-kinase inhibitors is suggested.

• A.A. Zeifman N.D. Zelinsky Institute of Organic Chemistry, RAS, Moscow, Russian Federation; Fusion Pharma LLC, Moscow, Russian Federation ; ФГБУ «Институт органической химии им. Н.Д. Зелинского РАН», Москва, Российская Федерация; ООО «Фьюжн Фарма», Москва, Российская Федерация
• E.Yu. Chelysheva Hematology Research Center, RF MH, Moscow, Russian Federation ; ФГБУ «Гематологический научный центр» МЗ РФ, Москва, Российская Федерация
• A.G. Tukrina Hematology Research Center, RF MH, Moscow, Russian Federation ; ФГБУ «Гематологический научный центр» МЗ РФ, Москва, Российская Федерация
• G.G. Chilov N.D. Zelinsky Institute of Organic Chemistry, RAS, Moscow, Russian Federation; Fusion Pharma LLC, Moscow, Russian Federation ; ФГБУ «Институт органической химии им. Н.Д. Зелинского РАН», Москва, Российская Федерация; ООО «Фьюжн Фарма», Москва, Российская Федерация

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