Cerebrovascular Disorders Associated with Ph-Negative Myeloproliferative Diseases

M.M. Tanashyan, Polina Igorevna Kuznetsova, A.L. Melikyan, A.A. Raskurazhev,

DOI:

https://doi.org/10.21320/2500-2139-2019-12-4-398-405

Background. Cerebrovascular disorders continue to be among the most common and socially significant worldwide. Among multiple reasons for circulatory disturbances special importance is attached to hemorheology and hemostasis disorders occurring also in patients with Ph-negative myeloproliferative diseases (MPD).

Aim. To investigate typical characteristics of the course of cerebrovascular disorders in patients with Ph-negative MPD.

Materials & Methods. The trial included 169 adult patients with neurological diseases. Among them the main group consisted of 104 patients aged 34 to 55 years (median 48.5 years) with Ph-negative MPD diagnosed at the National Medical Hematology Research Center. The control group consisted of 65 patients aged 51 to 58 years (median 55.5 years) with cerebrovascular diseases without concomitant hematological pathology.

Results. The incidence of acute ischemic strokes was 26.2 % in polycythemia vera (PV), 20.5 % in essential thrombocythemia (ET), and 8.7 % in primary myelofibrosis (PMF).

Conclusion. An acute ischemic stroke with a concurrent thrombotic occlusion of one of the major head arteries is a criterion for ruling out Ph-negative MPD. To identify cerebral lesions in patients with Ph-negative MPD (PV, ET, PMF) MRI of the brain is recommended.

  • M.M. Tanashyan Research Center of Neurology, 80 Volokolamskoe sh., Moscow, Russian Federation, 125367 ; ФГБНУ «Научный центр неврологии», Волоколамское ш., д. 80, Москва, Российская Федерация, 125367
  • Polina Igorevna Kuznetsova Research Center of Neurology, 80 Volokolamskoe sh., Moscow, Russian Federation, 125367 ; ФГБНУ «Научный центр неврологии», Волоколамское ш., д. 80, Москва, Российская Федерация, 125367
  • A.L. Melikyan National Medical Hematology Research Center, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167 ; ФГБУ «НМИЦ гематологии» Минздрава России, Новый Зыковский пр-д, д. 4а, Москва, Российская Федерация, 125167
  • A.A. Raskurazhev Research Center of Neurology, 80 Volokolamskoe sh., Moscow, Russian Federation, 125367 ; ФГБНУ «Научный центр неврологии», Волоколамское ш., д. 80, Москва, Российская Федерация, 125367
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Keywords:

cerebrovascular diseases, myeloproliferative diseases, thrombotic complications, hemorheology, hemostasis, ischemic stroke

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  • Polina Igorevna Kuznetsova, MD, PhD, Research Center of Neurology, 80 Volokolamskoe sh., Moscow, Russian Federation, 125367, ФГБНУ «Научный центр неврологии», Волоколамское ш., д. 80, Москва, Российская Федерация, 125367, e-mail: angioneurology0@gmail.com
2019-4

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Published

01.10.2019

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Vol. 12 No. 4 (2019)
MYELOID TUMORS

How to Cite

Tanashyan M.M., Kuznetsova P.I., Melikyan A.L., Raskurazhev A.A. Cerebrovascular Disorders Associated with Ph-Negative Myeloproliferative Diseases. Clinical Oncohematology. Basic Research and Clinical Practice. 2019;12(4):398–405. doi:10.21320/2500-2139-2019-12-4-398-405.

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