Diagnosis and Treatment of Thrombotic Thrombocytopenic Purpura Developed During Gestation: Literature Review and Case Report

This paper presents a literature review on state of art in issues of etiology, pathogenesis, clinical features and diagnosis of thrombotic thrombocytopenic purpura (ТТP or Moschcowitz’s disease). Data on a rare pathology of congenital ТТP (Upshaw—Schulman syndrome) and its manifestation during pregnancy are summarized. Various aspects of differential diagnosis for microangiopathic hemolytic anemia (МАHA), complicated issues in differential diagnosis for thrombotic microangiopathies (ТТP, hemolytic uremic syndrome, HELLP syndrome) during pregnancy are discussed. Specificity of clinical manifestations and differential diagnosis for acquired and congenital TTP in pregnant patients are considered. Issues of TTP treatment during pregnancy are exposed in detail.

• V.V. Voitsekhovskii Amur State Medical Academy, 95 Gor’kogo str., Blagoveshchensk, Amur Oblast, Russian Federation, 675000 ; Амурская государственная медицинская академия, ул. Горького, д. 95, Благовещенск, Амурская обл., Российская Федерация, 675000
• L.B. Filatov Yekaterinburg Consultative and Diagnostic Centre, 5 Suvorovskii per., Yekaterinburg, Sverdlov Oblast, Russian Federation, 620039 ; Екатеринбургский консультативно-диагностический центр, Суворовский пер., д. 5, Екатеринбург, Свердловская обл., Российская Федерация, 620039
• A.V. Pivnik D.D. Pletnev Moscow Clinical Scientific and Practical Center under the Department of Healthcare, 86 sh. Entuziastov, Moscow, Russian Federation, 111123 ; Московский клинический научно-практический центр им. Д.Д. Плетнева Департамента здравоохранения, ш. Энтузиастов, д. 86, Москва, Российская Федерация, 111123
• P.V. Avdonin N.K. Kol’tsov Institute of Developmental Biology, 26 Vavilova str., Moscow, Russian Federation, 119334 ; Институт биологии развития им. Н.К. Кольцова, ул. Вавилова, д. 26, Москва, Российская Федерация, 119334
• T.V. Esenina Amur Regional Clinical Hospital, 26 Voronkova str., Blagoveshchensk, Amur Oblast, Russian Federation, 675028 ; ГАУЗ АО «Амурская областная клиническая больница», ул. Воронкова, д. 26, Благовещенск, Амурская обл., Российская Федерация, 675028
• A.G. Sudakov Amur Regional Clinical Hospital, 26 Voronkova str., Blagoveshchensk, Amur Oblast, Russian Federation, 675028 ; ГАУЗ АО «Амурская областная клиническая больница», ул. Воронкова, д. 26, Благовещенск, Амурская обл., Российская Федерация, 675028

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