A Current View on Pathogenesis, Diagnosis, and Treatment of Some Rare Acute Leukemia Variants

Olga Yurevna Baranova, A.D. Shirin,

DOI:

https://doi.org/10.21320/2500-2139-2022-15-4-307-326

Fundamental discoveries in immunobiology of normal hematopoiesis, emerging views on malignant growth mechanisms together with further improvement of diagnostic capabilities led to a crucial change in perception of leukemiology as one of separate important areas of modern clinical oncohematology. The now available detailed molecular genetic classification of acute leukemias is being complemented by new disease variants. New categories of acute leukemias and progenitor cell tumors have been identified. Nevertheless, many issues related to pathogenesis and classification of some variants of this heterogeneous disease remain unsolved and require further study. The present review provides thorough analysis of some rare variants of acute leukemias which are particularly challenging in terms of pathogenesis, diagnosis, and choice of treatment.

  • Olga Yurevna Baranova NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478 ; ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478
  • A.D. Shirin NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478 ; ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478
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Keywords:

rare acute leukemia variants, blastic plasmacytoid dendritic cell neoplasm, early T-cell precursor acute lymphoblastic leukemia, acute leukemias of indeterminate lineage, pure erythroid leukemia, lineage switch

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Author Biography

  • Olga Yurevna Baranova, NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478, ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478

    MD, PhD

Published

01.10.2022

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Vol. 15 No. 4 (2022)
RARE HEMATOLOGICAL TUMORS AND SYNDROMES

How to Cite

Baranova O.Y., Shirin A.D. A Current View on Pathogenesis, Diagnosis, and Treatment of Some Rare Acute Leukemia Variants. Clinical Oncohematology. Basic Research and Clinical Practice. 2022;15(4):307–326. doi:10.21320/2500-2139-2022-15-4-307-326.

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