Кардиоваскулярная токсичность CAR T-клеточной терапии (обзор литературы)
ISSN (print) 1997-6933     ISSN (online) 2500-2139
2024-4
PDF_2024-17-4_404-414

Ключевые слова

гематологические злокачественные опухоли
CAR T-клеточная терапия
кардиоонкология
кардиоваскулярная токсичность
синдром выброса цитокинов
диагностика
лечение
мониторинг

Как цитировать

1.
Муртузалиев Ш.М., Салахеева Е.Ю., Кардовская С.А., Кириченко Ю.Ю., Сидерко Е.А., Беленков Ю.Н., Ильгисонис И.С. Кардиоваскулярная токсичность CAR T-клеточной терапии (обзор литературы). Клиническая онкогематология. 2024;17(4):404-414. doi:10.21320/2500-2139-2024-17-4-404-414

Ключевые слова

Аннотация

Благодаря совершенствованию скрининга, диагностики и методов лечения в современной онкологии значительно улучшились показатели выживаемости пациентов со злокачественными новообразованиями. Среди наиболее перспективных направлений в лечении выделяется новый метод иммунотерапии T-клетками, экспрессирующими химерные антигенные рецепторы (Chimeric Antigen Receptor T-cell, CAR T). Наиболее активно CAR T-клеточная терапия используется в онкогематологии. Однако, несмотря на эффективность новых методов лечения, в т. ч. CAR T-клеточной терапии, все больше накапливается данных о побочных эффектах. Одним из наиболее частых осложнений (около 1/3 всех больных) является кардиоваскулярная токсичность (КВТ), которая характеризуется высокими показателями летальности. Этим объясняется активное развитие нового междисциплинарного направления — кардиоонкологии, в рамках которой изучаются сердечно-сосудистые осложнения противоопухолевой терапии, методы их мониторинга и профилактики. В данном обзоре представлены известные к настоящему времени патофизиологические механизмы развития КВТ на фоне CAR T-клеточной терапии. Кроме того, обсуждаются клинические проявления, превентивная тактика и программы мониторинга кардиоваскулярных нежелательных явлений, встречающихся в практике гематолога.

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