ISSN (print) 1997-6933     ISSN (online) 2500-2139
Том 16 № 3 (2023), ОБЗОРЫ
Том 16 № 3 (2023)
ОБЗОРЫ

Роль лейкоцитов в формировании нейтрофильных внеклеточных ловушек и тромбообразовании при Ph-негативных миелопролиферативных новообразованиях (обзор литературы)

Опубликовано 20.02.2024
Болдукыз Толгонбаевна Джумабаева
ФГБУ «НМИЦ гематологии» Минздрава России, Новый Зыковский пр-д, д. 4, Москва, Российская Федерация, 125167
2023-3
PDF_2023-16-3_263-267

Ключевые слова

миелопролиферативные новообразования
нейтрофилы
тромбоз
нейтрофильные внеклеточные ловушки (NET)

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Джумабаева Б.Т. Роль лейкоцитов в формировании нейтрофильных внеклеточных ловушек и тромбообразовании при Ph-негативных миелопролиферативных новообразованиях (обзор литературы). Клиническая онкогематология. 2024;(3):263–267. doi:10.21320/2500-2139-2023-16-3-263-267.
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Аннотация

Тромботические осложнения нередко служат причиной смерти пациентов с хроническими Ph-негативными миелопролиферативными новообразованиями (МПН). Несмотря на многочисленные исследования, патогенез тромбообразования при МПН остается неясным. Его механизм сложный, многофакторный. Один из основных этапов тромбогенеза характеризуется активацией клеточных механизмов и образованием нейтрофильных внеклеточных ловушек (neutrophil extracellular traps — NET). NET состоят из нитей ДНК, гистонов, гранулярных белков и наряду с уничтожением патогенов обеспечивают идеальную матрицу для активации тромбоцитов и механизмов коагуляции.

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Библиографические ссылки

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