ISSN (print) 1997-6933     ISSN (online) 2500-2139
Vol. 17 No. 3 (2024), NATIONAL CLINICAL GUIDELINES
Vol. 17 No. 3 (2024)
NATIONAL CLINICAL GUIDELINES

National Clinical Guidelines on Diagnosis and Treatment of Ph-Negative Myeloproliferative Neoplasms (Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis) (Edition 2024)

Published 01.07.2024
Anait Levonovna Melikyan
National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167
https://orcid.org/0000-0002-2119-3775
I.N. Subortseva
National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167
https://orcid.org/0000-0001-9045-8653
A.M. Kovrigina
National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167
https://orcid.org/0000-0002-1082-8659
V.A. Shuvaev
Russian Research Institute of Hematology and Transfusiology, 16 2-ya Sovetskaya ul., Saint Petersburg, Russian Federation, 191024; Russian Medical Academy of Postgraduate Education, 2/1 Barrikadnaya ul., Moscow, Russian Federation, 125993
https://orcid.org/0000-0003-3536-0770
E.V. Morozova
RM Gorbacheva Research Institute, Pavlov University, 6/8 L’va Tolstogo ul., Saint Petersburg, Russian Federation, 197022
https://orcid.org/0000-0003-0752-0757
E.G. Lomaia
VA Almazov National Medical Research Center, 2 Akkuratova ul., Saint Petersburg, Russian Federation, 197341
https://orcid.org/0000-0003-3290-7961
V.V. Baykov
RM Gorbacheva Research Institute, Pavlov University, 6/8 L’va Tolstogo ul., Saint Petersburg, Russian Federation, 197022
https://orcid.org/0000-0002-9191-5091
O.Yu. Vinogradova
Moscow Municipal Center for Hematology, SP Botkin City Clinical Hospital, 5 2-i Botkinskii pr-d, Moscow, Russian Federation, 125284
https://orcid.org/0000-0002-3669-0141
S.V. Gritsaev
City Hospital No. 15, 4 korp 1 Avangardnaya ul., Saint Petersburg, Russian Federation, 198205
https://orcid.org/0000-0001-7586-4709
T.I. Ionova
NI Pirogov Clinic for High Medical Technology, Saint Petersburg State University, 154 Fontanki nab., Saint Petersburg, Russian Federation, 190103
https://orcid.org/0000-0002-9431-5286
P.I. Kuznetsova
Research Center for Neurology, 80 Volokolamskoe sh., Moscow, Russian Federation, 125367
https://orcid.org/0000-0002-4626-6520
L.A. Kuzmina
National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167
https://orcid.org/0000-0001-6201-6276
I.S. Martynkevich
Russian Research Institute of Hematology and Transfusiology, 16 2-ya Sovetskaya ul., Saint Petersburg, Russian Federation, 191024
https://orcid.org/0000-0001-5958-0490
T.A. Mitina
NF Vladimirskii Moscow Regional Research Clinical Institute, 61/2 Shchepkina ul., Moscow, Russian Federation, 129110
https://orcid.org/0000-0001-7493-0030
E.S. Polushkina
VI Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, 4 Akademika Oparina ul., Moscow, Russian Federation, 117997
https://orcid.org/0000-0002-1945-0154
T.I. Pospelova
Novosibirsk State Medical University, 52 Krasnyi pr-t, Novosibirsk, Russian Federation, 630091
https://orcid.org/0000-0002-1261-5470
M.A. Sokolova
National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167
https://orcid.org/0000-0003-1682-7005
A.B. Sudarikov
National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167
https://orcid.org/0000-0001-9463-9187
M.M. Tanashyan
Research Center for Neurology, 80 Volokolamskoe sh., Moscow, Russian Federation, 125367
https://orcid.org/0000-0002-5883-8119
A.G. Turkina
National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167
https://orcid.org/0000-0001-9947-2371
Yu.V. Shatokhin
Rostov State Medical University, 29 Nakhichevanskii per., Rostov-on-Don, Russian Federation, 344022
https://orcid.org/0000-0003-2246-2858
R.G. Shmakov
VI Krasnopolskii Moscow Regional Research Center for Obstetrics and Gynecology, 22A Pokrovka ul., Moscow, Russian Federation, 101000
https://orcid.org/0000-0002-2206-1002
E.N. Parovichnikova
National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167
https://orcid.org/0000-0001-6177-3566
2024-3
PDF_2024-17-3_291-334 (Russian)

Keywords

myeloproliferative neoplasms
polycythemia vera
essential thrombocythemia
primary myelofibrosis
JAK2
CALR
MPL
ASXL1
prognosis
hydroxyurea
interferon α-2b
ruxolitinib
fedratinib
anagrelide

How to Cite

Melikyan A.L., Subortseva I.N., Kovrigina A.M., Shuvaev V.A., Morozova E.V., Lomaia E.G., Baykov V.V., Vinogradova O.Y., Gritsaev S.V., Ionova T.I., Kuznetsova P.I., Kuzmina L.A., Martynkevich I.S., Mitina T.A., Polushkina E.S., Pospelova T.I., Sokolova M.A., Sudarikov A.B., Tanashyan M.M., Turkina A.G., Shatokhin Y.V., Shmakov R.G., Parovichnikova E.N. National Clinical Guidelines on Diagnosis and Treatment of Ph-Negative Myeloproliferative Neoplasms (Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis) (Edition 2024). Clinical Oncohematology. 2024;(3):291–334. doi:10.21320/2500-2139-2024-17-3-291-334.
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Keywords

Abstract

The development of National clinical guidelines on diagnosis and treatment of Ph-negative myeloproliferative neoplasms provides the knowledge basis for decision making in diagnosis, therapy, prevention, and rehabilitation in compliance with evidence-based medicine principles in order to ensure appropriate medical care in a particular clinical setting. The clinical guidelines underly the choice of optimal methods of diagnosis, therapy, prevention, and rehabilitation as part of a patient’s medical care, the development of criteria for the assessment of medical care quality, medical care standards, medical care procedures, setting standards on equipment and management of diagnostic and therapeutic procedures, and provision of continuous medical education and advanced training for healthcare professionals. In 2013, a working group was formed to develop and formulate clinical guidelines on the treatment of myeloproliferative neoplasms. These guidelines were first published in 2014, afterwards they were revised and republished. The dynamic development of current hematology presupposes constant updating of knowledge and implementation of new diagnosis and treatment methods in clinical practice. In this context, clinical guidelines present a dynamic document to be continuously amended, expanded, and updated in accordance with scientific findings and new requirements of specialists who are directly involved in treatment activities. The present edition is an upgraded version of clinical guidelines with updated information on classification, diagnosis, prognosis, current methods of therapy, and their efficacy and tolerability assessment. The guidelines are intended for oncologists, hematologists, healthcare executives, and medical students.

PDF_2024-17-3_291-334 (Russian)

References

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