ISSN (print) 1997-6933     ISSN (online) 2500-2139
Vol. 17 No. 2 (2024), REVIEWS
Vol. 17 No. 2 (2024)
REVIEWS

Plasma Cell Tumors in Hematological Classifications of 2022: WHO-HAEM5 (WHO, 5th edition) and ICC (International Consensus Classification). A Clinician’s View

Published 01.04.2024
Sergei Vyacheslavovich Semochkin
PA Gertsen Moscow Oncology Research Institute, branch of the NMRC of Radiology, 3 2-i Botkinskii pr-d, Moscow, Russian Federation, 125284; NI Pirogov Russian National Research Medical University, 1 Ostrovityanova ul., Moscow, Russian Federation, 117997
PDF_2024-17-2_94-108 (Russian)

Keywords

multiple myeloma
monoclonal gammopathy of undetermined significance
cold agglutinin disease
lymphoplasmacytic lymphoma
AL amyloidosis

How to Cite

Semochkin S.V. Plasma Cell Tumors in Hematological Classifications of 2022: WHO-HAEM5 (WHO, 5th edition) and ICC (International Consensus Classification). A Clinician’s View. Clinical Oncohematology. 2024;(2):94–108. doi:10.21320/2500-2139-2024-17-2-94-108.
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Abstract

In 2022, the hematological community was faced with a rather non-trivial event of simultaneous publication of two competitive classifications of hematopoietic and lymphoid tumors drawn up by different teams of the international leading experts. During the last 20 years, the generally recognized standard used for diagnosis was provided by several consecutive editions of classifications of hematological neoplasms published by the World Health Organization (WHO) in 2001, 2008, and 2016. Since the 4th edition of the WHO classification (WHO-HAEM4), new clinicopathologic, biological, and molecular knowledge has accumulated in this area, which promoted the refinement of diagnostic criteria for some diseases, the emergence of new terms, and the endorsement of notions previously defined as requiring further clarification. As a result, the next 5th edition of the WHO classification of tumours of haematopoietic and lymphoid tissues (WHO-HAEM5) was prepared and published as a preliminary article in the Leukemia. In this regard, it is worth noting that the final version of the WHO Blue Book was not released in 2023 and, therefore, can still be accomplished by some additions. Furthermore, in the same year of 2022, the Blood published the article “The International Consensus Classification of Mature Lymphoid Neoplasms” abbreviated to ICC. The authors of the two classifications hardly overlap. The present review compares these classifications with regard to new diagnostic criteria and verification of concrete clinicopathologic categories. The review largely focuses on plasma cell tumors and related B-cell lymphoproliferative diseases characterized by monoclonal immunoglobulin secretion.

PDF_2024-17-2_94-108 (Russian)

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