ISSN (print) 1997-6933     ISSN (online) 2500-2139
Vol. 16 No. 4 (2023), LYMPHOID TUMORS
Vol. 16 No. 4 (2023)
LYMPHOID TUMORS

Endoscopic Semiotics of the Gastritis-Like Form of Primary Gastric Non-Hodgkin Lymphomas

Published 20.02.2024
Valeriya Vitalevna Lozovaya
NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478
O.A. Malikhova
NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478; Russian Medical Academy of Postgraduate Education, 2/1 Barrikadnaya ul., Moscow, Russian Federation, 125993
A.O. Tumanyan
NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478
#4 2023
PDF_2023-16-4_380-386 (Russian)

Keywords

primary gastric non-Hodgkin lymphomas
MALT-lymphoma
gastritis-like form of primary gastric NHLs
endoscopic diagnosis

How to Cite

Lozovaya V.V., Malikhova O.A., Tumanyan A.O. Endoscopic Semiotics of the Gastritis-Like Form of Primary Gastric Non-Hodgkin Lymphomas. Clinical Oncohematology. 2024;(4):380–386. doi:10.21320/2500-2139-2023-16-4-380-386.
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Abstract

Aim. To characterize the main differentially significant endoscopic features specific to the gastritis-like form of primary gastric non-Hodgkin lymphomas (NHL).

Materials & Methods. This prospective study analyzes the results of complex endoscopic diagnosis in 43 patients with primary gastric NHL. They were examined and treated at the NN Blokhin National Medical Cancer Research Center from 2019 to 2023. The patients were 30–70 years of age, those over the age of 50 predominated and accounted for 79 % (n = 34). There were 33 women and 10 men. The control group included 45 patients with gastritis-like malignant gastric tumors: adenocarcinoma and signet-ring cell cancer.

Results. The morphological analysis yielded a diagnosis of MALT-lymphoma in 90.7 % (n = 39) and diffuse large B-cell lymphoma in 9.3 % (n = 4) of cases. Sensitivity, specificity, and accuracy of the clarification methods of complex endoscopic diagnosis were considerably higher compared to white-light mode examination. According to the results of complex endoscopic analysis, all patients were stratified into 4 groups with different types of H. pylori-induced atrophic gastritis (n = 10; 23.25 %), erosive gastritis (n = 10; 23.25 %), hyperplastic gastritis (n = 8; 18.6 %), and combined gastritis (n = 15; 34.9 %). The focus was laid on identifying the main differentially significant endoscopic features specific to the gastritis-like form of primary gastric NHL which distinguish it from the lesions in other malignant tumors.

Conclusion. The complex examination using 4 concrete clarification methods of endoscopic diagnosis is indispensable to properly interpret the detected changes and timely diagnose the gastritis-like form of primary gastric NHL. These include narrow-band imaging (NBI/BLI and LCI), close-focus and magnification examinations, combined narrow-band imaging and magnification examination, as well as endosonography.

PDF_2023-16-4_380-386 (Russian)

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