ISSN (print) 1997-6933     ISSN (online) 2500-2139
Vol. 14 No. 3 (2021), LYMPHOID TUMORS
Vol. 14 No. 3 (2021)
LYMPHOID TUMORS

Obesity as a Poor Prognostic Factor in Multiple Myeloma

Published 01.07.2021
Evgenii Sergeevich Mikhailov
VA Almazov National Medical Research Center, 2 Akkuratova str., Saint Petersburg, Russian Federation, 197341
G.N. Salogub
VA Almazov National Medical Research Center, 2 Akkuratova str., Saint Petersburg, Russian Federation, 197341
S.S. Bessmeltsev
Russian Research Institute of Hematology and Transfusiology, 16 2-ya Sovetskaya str., Saint Petersburg, Russian Federation, 191024
PDF_2021-14-3-315-320 (Russian)

Keywords

multiple myeloma
obesity
prognosis
survival

How to Cite

Mikhailov E.S., Salogub G.N., Bessmeltsev S.S. Obesity as a Poor Prognostic Factor in Multiple Myeloma. Clinical Oncohematology. 2021;(3):315–320. doi:10.21320/2500-2139-2021-14-3-315-320.
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Abstract

Aim. To assess the impact of obesity and overweight on the outcomes of multiple myeloma (MM) treatment.

Materials & Methods. The present retrospective study enrolled 214 patients with newly diagnosed MM. The median age was 59 years (range 29–89 years), male patients accounted for 40.2 %. The analysis focused on complication incidence, overall survival, and time to the second-line therapy depending on body mass index (BMI) at disease onset.

Results. In the groups of patients with BMI > 35 kg/m2 and BMI ≤ 35 kg/m2 the median overall survival was 42 and 95 months, respectively (hazard ratio [HR] 0.17; 95% confidence interval [95% CI] 0.08–0.37; p < 0.05). In the group of patients with obesity ≥ grade 2 the median time to the second-line therapy was 25 months, being less than in the group of patients with BMI ≤ 35 kg/m2 (43 months; HR 0.58; 95% CI 0.31–0.99; p < 0.05). As a result of therapy, the incidence of corticosteroid-associated hyperglycemia and infectious complications as well as the rate of delayed initiation of the next cycle and dose reduction of anticancer drugs were significantly higher in patients with BMI > 35 kg/m2 (p < 0.05).

Conclusion. Obesity ≥ grade 2 is a poor prognostic factor for complications and is associated with diminishing outcomes of ММ treatment. Accompanying morbid obesity leads to a higher incidence of therapy complications longer intervals between chemotherapy courses and drug dose reduction.

PDF_2021-14-3-315-320 (Russian)

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