ISSN (print) 1997-6933     ISSN (online) 2500-2139
Vol. 14 No. 1 (2021), LYMPHOID TUMORS
Vol. 14 No. 1 (2021)
LYMPHOID TUMORS

Chronic Lymphocytic Leukemia in Blood Relatives: Two Case Reports of Male Siblings

Published 01.01.2021
Nadezhda Viktorovna Kurkina
NP Ogarev National Research Mordovia State University, 68 Bolshevistskaya str., Saransk, Russian Federation, 430005; Republican Clinical Hospital No. 4, 32 Ul’yanova str., Saransk, Russian Federation, 430032
E.A. Repina
NP Ogarev National Research Mordovia State University, 68 Bolshevistskaya str., Saransk, Russian Federation, 430005
PDF_2021-14-1-69-72 (Russian)

Keywords

chronic lymphocytic leukemia
heredity
ibrutinib
refractoriness
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How to Cite

Kurkina N.V., Repina E.A. Chronic Lymphocytic Leukemia in Blood Relatives: Two Case Reports of Male Siblings. Clinical Oncohematology. 2021;(1):69–72. doi:10.21320/2500-2139-2021-14-1-69-72.
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Abstract

In recent years there are more and more evidences for a hereditary factor in malignant lymphoproliferative disorders. Various lymphoid tumors are diagnosed in blood relatives. This is most frequently observed in chronic lymphocytic leukemia: 13.3 % vs. 8.8 % in non-Hodgkin’s lymphoma and 5.9 % in Hodgkin’s lymphoma. This paper presents two case reports of chronic lymphocytic leukemia in blood relatives (male siblings). Besides, in one of them the efficacy of targeted therapy with ibrutinib is estimated.

PDF_2021-14-1-69-72 (Russian)

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