Комбинация ибрутиниба и венетоклакса в терапии хронического лимфолейкоза: обзор последних данных клинических исследований
ISSN (print) 1997-6933     ISSN (online) 2500-2139
2023-1
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Ключевые слова

ибрутиниб
ингибиторы BTK
венетоклакс
ингибиторы BCL-2
таргетные препараты
хронический лимфолейкоз

Как цитировать

1.
Петренко А.А., Кислова М.И., Дмитриева Е.А., Никитин Е.А., Птушкин В.В. Комбинация ибрутиниба и венетоклакса в терапии хронического лимфолейкоза: обзор последних данных клинических исследований. Клиническая онкогематология. 2024;16(1):37-45. doi:10.21320/2500-2139-2023-16-1-37-45

Ключевые слова

Аннотация

Появление ингибиторов тирозинкиназы Брутона (BTK) изменило лечение пациентов с хроническим лимфолейкозом (ХЛЛ). Ибрутиниб, первый в своем классе ингибитор BTK, продемонстрировал высокую эффективность в многочисленных клинических исследованиях. Однако использование ингибиторов BTK в качестве монотерапии требует непрерывного лечения. Резистентность к ингибиторам BTK и тяжелые побочные эффекты неизбежно возникают при монотерапии ибрутинибом, что часто приводит к неэффективности лечения. Комбинация ингибитора BCL-2 венетоклакса с ингибитором BTK может улучшить эффективность терапии за счет синергизма действия препаратов на разные субпопуляции клеток ХЛЛ. Комбинированная терапия может привести к более глубоким ответам, обеспечивая потенциально фиксированную продолжительность лечения. В настоящем обзоре, сосредоточив внимание на комбинации ибрутиниба и венетоклакса, мы обобщаем последние данные клинических исследований, а также отвечаем на вопрос, касающийся обоснованности комбинированной терапии с точки зрения ее эффективности и профиля безопасности.

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