трансфузионная зависимость

Клиническая эффективность хелаторной терапии у пациентов с миелодиспластическим синдромом низкого риска

ОБЗОРЫ , , , ,

С.В. Грицаев, И.И. Кострома, А.А. Жернякова

ФГБУ «Российский НИИ гематологии и трансфузиологии ФМБА», ул. 2-я Советская, д. 16, Санкт-Петербург, Российская Федерация, 191024

Для переписки: Сергей Васильевич Грицаев, д-р мед. наук, ул. 2-я Советская, д. 16, Санкт-Петербург, Российская Федерация, 191024; тел.: +7(812)717-54-68; e-mail: gritsaevsv@mail.ru

Для цитирования: Грицаев С.В., Кострома И.И., Жернякова А.А. Клиническая эффективность хелаторной терапии у пациентов с миелодиспластическим синдромом низкого риска. Клиническая онкогематология. 2019;12(2):120–4.

DOI: 10.21320/2500-2139-2019-12-2-120-124

РЕФЕРАТ

В обзоре литературы представлены данные, свидетельствующие о возможности улучшения показателей крови и выживаемости у больных с миелодиспластическим синдромом низкого риска с трансфузионной зависимостью при назначении хелаторов железа. Адекватность дозы и длительность терапии — основные условия клинической эффективности хелаторов. Снижению токсических осложнений может способствовать перевод больного на прием новой формулы деферазирокса, не требующей предварительного растворения в жидкости.

Ключевые слова: миелодиспластический синдром, низкий риск, трансфузионная зависимость, хелаторы железа, выживаемость.

Получено: 20 августа 2018 г.

Принято в печать: 2 февраля 2019 г.

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