ингибиторы BTK

Комбинация ибрутиниба и венетоклакса в терапии хронического лимфолейкоза: обзор последних данных клинических исследований

ОБЗОРЫ , , , , ,

А.А. Петренко1,2, М.И. Кислова1, Е.А. Дмитриева1, Е.А. Никитин1,2, В.В. Птушкин1,2,3

1 ГБУЗ «Городская клиническая больница им. С.П. Боткина ДЗМ», 2-й Боткинский пр-д, д. 5, Москва, Российская Федерация, 125284

2 ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России, ул. Баррикадная, д. 2/1, Москва, Российская Федерация, 125993

3 ФГАОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России, ул. Островитянова, д. 1, Москва, Российская Федерация, 117997

Для переписки: Мария Игоревна Кислова, 2-й Боткинский пр-д, д. 5, Москва, Российская Федерация, 125284; e-mail: xkislovamariax@gmail.com

Для цитирования: Петренко А.А., Кислова М.И., Дмитриева Е.А. и др. Комбинация ибрутиниба и венетоклакса в терапии хронического лимфолейкоза: обзор последних данных клинических исследований. Клиническая онкогематология. 2023;16(1):37–45.

DOI: 10.21320/2500-2139-2023-16-1-37-45

РЕФЕРАТ

Появление ингибиторов тирозинкиназы Брутона (BTK) изменило лечение пациентов с хроническим лимфолейкозом (ХЛЛ). Ибрутиниб, первый в своем классе ингибитор BTK, продемонстрировал высокую эффективность в многочисленных клинических исследованиях. Однако использование ингибиторов BTK в качестве монотерапии требует непрерывного лечения. Резистентность к ингибиторам BTK и тяжелые побочные эффекты неизбежно возникают при монотерапии ибрутинибом, что часто приводит к неэффективности лечения. Комбинация ингибитора BCL-2 венетоклакса с ингибитором BTK может улучшить эффективность терапии за счет синергизма действия препаратов на разные субпопуляции клеток ХЛЛ. Комбинированная терапия может привести к более глубоким ответам, обеспечивая потенциально фиксированную продолжительность лечения. В настоящем обзоре, сосредоточив внимание на комбинации ибрутиниба и венетоклакса, мы обобщаем последние данные клинических исследований, а также отвечаем на вопрос, касающийся обоснованности комбинированной терапии с точки зрения ее эффективности и профиля безопасности.

Ключевые слова: ибрутиниб, ингибиторы BTK, венетоклакс, ингибиторы BCL-2, таргетные препараты, хронический лимфолейкоз.

Получено: 17 октября 2022 г.

Принято в печать: 10 ноября 2022 г.

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