Кардиотоксичность высокодозной химиотерапии и аутологичной трансплантации костного мозга при онкогематологических заболеваниях

В.О. Саржевский, Д.С. Колесникова, В.Я. Мельниченко, В.П. Тюрин

ФГБУ «Национальный медико-хирургический центр им. Н.И. Пирогова» МЗ РФ, Москва, Российская Федерация


РЕФЕРАТ

В обзоре представлены современные данные, касающиеся кардиотоксичности высокодозной химиотерапии и аутологичной трансплантации костного мозга (периферических кроветворных стволовых клеток) при онкогематологических заболеваниях. Дана подробная информация о методах исследования, используемых для оценки кардиотоксичности, представлены клинические особенности кардиальных осложнений на всех этапах проведения трансплантации (мобилизация, кондиционирование, ранний посттрансплантационный период) и в более поздние сроки после окончания лечения. Приведены подходы к профилактике и лечению кардиотоксичности у данной категории больных.


Ключевые слова: кардиотоксичность, высокодозная химиотерапия, аутологичная трансплантация костного мозга.

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