Изменения желудочно-кишечного тракта при высокодозной химиотерапии и аутологичной трансплантации костного мозга у пациентов с онкогематологическими заболеваниями

В.О. Саржевский, Е.Г. Смирнова, В.Я. Мельниченко

ФГБУ «Национальный медико-хирургический центр им. Н.И. Пирогова» Минздрава РФ, Москва, Российская Федерация

Для цитирования: Саржевский В.О., Смирнова Е.Г., Мельниченко В.Я. Изменения желудочно-кишечного тракта при высокодозной химиотерапии и аутологичной трансплантации костного мозга у пациентов с онкогематологическими заболеваниями. Клин. онкогематол. 2014; 7(3): 343–53.


РЕФЕРАТ

Практически у всех больных с онкогематологическими заболеваниями, получающих высокодозную химиотерапию (ВДХТ) с аутологичной трансплантацией костного мозга (периферических гемопоэтических стволовых клеток — аутоТГСК), определяются различной степени выраженности изменения со стороны ЖКТ. Указанные изменения (мукозиты) существенно ухудшают качество жизни пациентов, способствуют развитию инфекционных осложнений и в ряде случаев могут быть причиной летального исхода. Авторы, подчеркивая важность изменений ЖКТ при ВДХТ с аутоТГСК, освещают этиологические и патогенетические факторы мукозитов, дают подробную информацию о клинической оценке, методах исследования, профилактике и лечению данного осложнения трансплантации у пациентов с онкогематологическими заболеваниями.


Ключевые слова: высокодозная химиотерапия, аутологичная трансплантация костного мозга, мукозит.

Принято в печать: 26 мая 2014 г.

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