Sclerosing Angiomatoid Nodular Transformation of Spleen and Renal Cancer Associated with Reactive Cytotoxic T-Cell Population: A Rare Case Report

Nikolai Igorevich Stuklov, A.M. Vukovic, I.M. Zhukova, S.-M.S. Nazarkina, A. Hamo, V.A. Doronin, A.M. Kovrigina,

DOI:

https://doi.org/10.21320/2500-2139-2026-19-3-335-343

Sclerosing angiomatoid nodular transformation (SANT) is a rare benign non-neoplastic vascular disease of the spleen which is characterized by multiple angiomatoid nodes separated by fibrous stroma. In most cases, SANT is asymptomatic and usually comes to light as an incidental finding on an ultrasound scan. T-cell clone of uncertain significance (T-CUS) and reactive cytotoxic Т-cell population may be induced by virus infections, autoimmune diseases, or tumors. These disorders require differential diagnosis with large granular lymphocyte (T- or NK-cell) leukemia which in 1/3 of patients is marked by asymptomatic cytopenia on diagnosis date. This paper reviews the literature and is the first to describe the combination of several pathologic events including SANT of the spleen and reactive cytotoxic Т-cell population, identified during the examination for the tumor of the right kidney with aggressive fatal course.

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Keywords:

sclerosing angiomatoid nodular transformation of the spleen, reactive cytotoxic Т-cell population, large granular lymphocyte T-cell leukemia

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  • Nikolai Igorevich Stuklov, Prof., MD, PhD, RUDN University, 6 Miklukho-Maklaya ul., Moscow, Russian Federation, 117198, e-mail: stuklovn@gmail.com

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Published

01.07.2026

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Vol. 19 No. 3 (2026)
RARE HEMATOLOGICAL TUMORS AND SYNDROMES

How to Cite

Stuklov N.I., Vukovic A.M., Zhukova I.M., et al. Sclerosing Angiomatoid Nodular Transformation of Spleen and Renal Cancer Associated with Reactive Cytotoxic T-Cell Population: A Rare Case Report. Clinical Oncohematology. Basic Research and Clinical Practice. 2026;19(3):335–343. doi:10.21320/2500-2139-2026-19-3-335-343.

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