Association between HLA-DRB1 alleles and response to imatinib in chronic myeloid leukemia

The article presents analysis of association between the HLA-DRB1 gene alleles and the response to imatinib in the patients with Ph-positive chronic myeloid leukemia (Ph+ CML). HLA class II alleles, DRB1 locus, were determined using PCR-SSP. The predictors of optimal response to imatinib in 3 to 18-months treatment of CML are HLA-DRB1*16(02), HLA-DRB1*17(03), and HLA-DRB1*08 specificities. Immunogenetic markers of imatinib treatment failure are HLA-DRB1*11(05), HLA-DRB1*12(05), and HLA-DRB1*14(06) alleles. The results obtained can be used for the development of individual long-term prognosis for chronic myeloid leukemia and optimization of the treatment choice.

• E.G. Ovsyannikova Astrakhan State Medical Academy, RF Ministry of Health, Astrakhan, Russian Federation ; ГБОУ ВПО «Астраханская государственная медицинская академия» МЗ РФ, Астрахань, Российская Федерация
• I.L. Davydkin Research Institute of Hematology, Transfusiology, and Intensive Care, Samara State Medical University, RF Ministry of Health, Samara, Russian Federation ; НИИ гематологии, трансфузиологии и интенсивной терапии ГБОУ ВПО «Самарский государственный медицинский университет» МЗ РФ, Самара, Российская Федерация
• E.A. Popov Astrakhan State Medical Academy, RF Ministry of Health, Astrakhan, Russian Federation ; ГБОУ ВПО «Астраханская государственная медицинская академия» МЗ РФ, Астрахань, Российская Федерация
• L.V. Zaklyakova Astrakhan State Medical Academy, RF Ministry of Health, Astrakhan, Russian Federation ; ГБОУ ВПО «Астраханская государственная медицинская академия» МЗ РФ, Астрахань, Российская Федерация
• B.N. Levitan Astrakhan State Medical Academy, RF Ministry of Health, Astrakhan, Russian Federation ; ГБОУ ВПО «Астраханская государственная медицинская академия» МЗ РФ, Астрахань, Российская Федерация

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