Case of Pneumocystis Pneumonia after High-Dose Chemotherapy with Autologous Hematopoietic Transplantation
DOI:
https://doi.org/10.21320/2500-2139-2014-7-4-583-586Pneumocystis pneumonia is a rare complication of a high-dose chemotherapy and autologous bone marrow/peripheral hematopoietic stem cells transplantation in patients with hematological malignances. The absence of typical clinical symptoms and the probability of a lethal outcome require a special approach to this problem. A brief review of literature and presented clinical case give an idea of clinical manifestations, course, diagnostic approaches, prevention, and treatment of pneumocystis pneumonia in this category of patients.
- Walzer P.D., Perl D.P., Krogstad D.J. et al. Pneumocystis carinii pneumonia in the United States: epidemiologic, diagnostic, and clinical features. Natl. Cancer Inst. Monogr. 1976; 43: 55–63.
- Green H., Paul M., Vidal L. et al. Prophylaxis of Pneumocystis pneumonia in immunocompromised non-HIV-infected patients: systematic review and metaanalysis of randomized controlled trials. Mayo Clin. Proc. 2007; 82(9): 1052–9. DOI: https://doi.org/10.4065/82.9.1052
- Colby C., McAfee S., Sackstein R. et al. A prospective randomized trial comparing the toxicity and safety of atovaquone with trimethoprim/ sulfamethoxazole as Pneumocystis carinii pneumonia prophylaxis following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1999; 24(8): 897–902. DOI: https://doi.org/10.1038/sj.bmt.1702004
- Sattler F.R., Cowan R., Nielsen D.M. et al. Trimethoprim-sulfamethoxazole compared with pentamidine for treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A prospective, noncrossover study. Ann. Intern. Med. 1988; 109(4): 280–7. DOI: https://doi.org/10.7326/0003-4819-109-4-280
- Hughes W., Leoung G., Kramer F. et al. Comparison of atovaquone (566C80) with trimethoprim-sulfamethoxazole to treat Pneumocystis carinii pneumonia in patients with AIDS. N. Engl. J. Med. 1993; 328(21): 1521–7. DOI: https://doi.org/10.1056/NEJM199305273282103
- Metzner B., Gruneisl R., Gebauer W. et al. Late infectious complications after high-dose therapy and autologous blood stem cell transplantation. Med. Klin. (Munich) 2002; 97(11): 650–8. DOI: https://doi.org/10.1007/s00063-002-1208-y
- Decaudin D., Brousse N., Brice P. et al. Efficacy of autologous stem cell transplantation in mantle cell lymphoma: a 3-year follow-up study. Bone Marrow Transplant. 2000; 25(3): 251–6. DOI: https://doi.org/10.1038/sj.bmt.1702135
- Chen C.S., Boeckh M., Seidel K. Incidence, risk factors, and mortality from pneumonia developing late after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2003; 32(5): 515–22. DOI: https://doi.org/10.1038/sj.bmt.1704162
- Chuu W.M., Catlett J.P., Perry D.J. Concurrent Pneumocystis carinii and cytomegalovirus pneumonia after autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 1999; 23(10): 1087–9. DOI: https://doi.org/10.1038/sj.bmt.1701739
- Kato H., Yamamoto K., Taji H. et al. Interstitial pneumonia after autologous hematopoietic stem cell transplantation in B-cell non-Hodgkin lymphoma. Clin. Lymphoma Myeloma Leuk. 2011; 11(6): 483–9. DOI: https://doi.org/10.1016/j.clml.2011.06.011
- Munker R., Lazarus H.M., Atkinson K. The BMT Data Book, 2nd ed. Cambridge University Press, 2009: 245. DOI: https://doi.org/10.1017/CBO9780511575525
License
Copyright (c) 2014 Clinical Oncohematology

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.



