Prolonged chemotherapy for angioimmunoblastic T-cell lymphoma

Introduction: Current СНОР-like therapy for angioimmunoblastic T-cell lymphoma demonstrates unsatisfactory results with respect to the achievement of complete remission. It indicates the need in the search for new approaches to therapy of angioimmunoblastic T-cell lymphoma.

Objective: To define the rational approaches to the diagnosis and treatment of angioimmunoblastic T-cell lymphoma (AITL).

Materials and methods: Within the period from 2002 to 2012, we followed-up 15 patients with angioimmunoblastic T-cell lymphoma, with median age of 61 years (range 29–77) and the male/female ratio of 11/4. All patients had stage IV disease; the bone marrow, lungs, spleen, and skin were involved in 14 (93 %), 9 (60 %), 12 (80 %), and 6 (40 %) patients, respectively.

Results: We used prolonged chemotherapy GMALL 2002 and ALL-2009 regimens for treatment of angioimmunoblastic T-cell lymphoma (11 patients). Complete remission was achieved in 55 % of cases with median follow up of 33 mouths.

Conclusion: The usage of short-term chemotherapy programs (CHOP-like) for treatment of angioimmunoblastic T-cell lymphoma doesn’t seem to give good results. Administration of prolonged chemotherapy is more appropriate and allows achieving remission of the disease.

• N.G. Chernova Hematology Research Center, RF MH, Moscow, Russian Federation ; ФГБУ «Гематологический научный центр» МЗ РФ, Москва, Российская Федерация
• Yu.E. Vinogradova I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation ; ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова», Москва, Российская Федерация
• Yu.V. Sidorova Hematology Research Center, RF MH, Moscow, Russian Federation ; ФГБУ «Гематологический научный центр» МЗ РФ, Москва, Российская Федерация
• I.B. Kaplanskaya Hematology Research Center, RF MH, Moscow, Russian Federation ; ФГБУ «Гематологический научный центр» МЗ РФ, Москва, Российская Федерация
• E.A. Gilyazitdinova Hematology Research Center, RF MH, Moscow, Russian Federation ; ФГБУ «Гематологический научный центр» МЗ РФ, Москва, Российская Федерация
• L.G. Gorenkova Hematology Research Center, RF MH, Moscow, Russian Federation ; ФГБУ «Гематологический научный центр» МЗ РФ, Москва, Российская Федерация
• D.S. Marin Hematology Research Center, RF MH, Moscow, Russian Federation ; ФГБУ «Гематологический научный центр» МЗ РФ, Москва, Российская Федерация
• A.M. Kremenetskaya Hematology Research Center, RF MH, Moscow, Russian Federation ; ФГБУ «Гематологический научный центр» МЗ РФ, Москва, Российская Федерация
• A.I. Vorobyev Hematology Research Center, RF MH, Moscow, Russian Federation ; ФГБУ «Гематологический научный центр» МЗ РФ, Москва, Российская Федерация
• S.K. Kravchenko Hematology Research Center, RF MH, Moscow, Russian Federation ; ФГБУ «Гематологический научный центр» МЗ РФ, Москва, Российская Федерация

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