Efficacy and Toxicity of Therapy for Patients with Intermediate-Risk Hodgkin’s Lymphoma: Results of Multicenter Randomized Study

Objective. To study the efficacy and toxicity of various treatment schemes for patients with intermediate-risk Hodgkin’s lymphoma (HL).

Methods. This article presents an analysis of the immediate results of complex treatment of 103 intermediate-risk HL patients (stage IIA and IIB with one or more unfavorable prognostic factors), who have been treated at the National Cancer Institute (Kyiv) and the Crimean Oncology Dispensary (Simferopol) from 2009 to 2014 (study group). Patients were divided into two study groups and treated with 6xBEACOPP-esc or 2xBEACOPP-esc + 4xABVD, followed by radiotherapy on the affected areas at a dose of 30–36 Gy in both groups. The control group included 53 patients who received treatment according to the 6xABVD scheme, followed by radiotherapy on the affected areas at a dose of 30–36 Gy over the period from 2000 to 2008. The immediate efficiency of the therapy, as well as its toxicity was evaluated.

Results. The study results demonstrated that treatment of the intermediate-risk HL patients that included 6xBEACOPP-esc and 2xBEACOPP-esc + 4xABVD proved to be an effective approach. Overall immediate efficacy of 2xBEACOPP-esc + 4xABVD protocol with subsequent radiation therapy was 95.83 %, and that of the 6xBEACOPP-esc was 96.36 %, which was significantly higher than the efficacy in the control group (83.02 %; p < 0.05). The toxicity level of the therapy was lower in the 2xBEACOPP-esc + 4xABVD group than that in the 6xBEACOPP-esc group (63.19 % and 83.03 %, respectively, p < 0.001).

Conclusion. Treatment of patients with intermediate-risk HL with 2xBEACOPP-esc + 4xABVD is comparable to that with 6xBEACOPP-esc, but it demonstrates a better toxicity profile.

• I.A. Kryachok National Cancer Institute, 33/43 Lomonosova str., Kyiv, Ukraine, 03022 ; Национальный институт рака, ул. Ломоносова, д. 33/43, Киев, Украина, 03022
• Alim Anvarovich Amdiev V.M. Efetov Crimean National Clinical Oncology Dispensary, 49a Bespalova str., Simferopol, Russian Federation, 295023 ; ГБУЗ «Крымский республиканский онкологический клинический диспансер им. В.М. Ефетова», ул. Беспалова, д. 49а, Симферополь, Российская Федерация, 295023
• I.B. Titorenko National Cancer Institute, 33/43 Lomonosova str., Kyiv, Ukraine, 03022 ; Национальный институт рака, ул. Ломоносова, д. 33/43, Киев, Украина, 03022
• E.M. Aleksik National Cancer Institute, 33/43 Lomonosova str., Kyiv, Ukraine, 03022 ; Национальный институт рака, ул. Ломоносова, д. 33/43, Киев, Украина, 03022
• E.O. Ul’yanchenko National Cancer Institute, 33/43 Lomonosova str., Kyiv, Ukraine, 03022 ; Национальный институт рака, ул. Ломоносова, д. 33/43, Киев, Украина, 03022
• O.I. Novosad National Cancer Institute, 33/43 Lomonosova str., Kyiv, Ukraine, 03022 ; Национальный институт рака, ул. Ломоносова, д. 33/43, Киев, Украина, 03022
• E.S. Filonenko National Cancer Institute, 33/43 Lomonosova str., Kyiv, Ukraine, 03022 ; Национальный институт рака, ул. Ломоносова, д. 33/43, Киев, Украина, 03022
• M.I. Kasich V.M. Efetov Crimean National Clinical Oncology Dispensary, 49a Bespalova str., Simferopol, Russian Federation, 295023 ; ГБУЗ «Крымский республиканский онкологический клинический диспансер им. В.М. Ефетова», ул. Беспалова, д. 49а, Симферополь, Российская Федерация, 295023
• M.Ya. Kiseleva V.M. Efetov Crimean National Clinical Oncology Dispensary, 49a Bespalova str., Simferopol, Russian Federation, 295023 ; ГБУЗ «Крымский республиканский онкологический клинический диспансер им. В.М. Ефетова», ул. Беспалова, д. 49а, Симферополь, Российская Федерация, 295023

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