Anorexia-Cachexia Syndrome in Cancer Patients

Anton Vladimirovich Snegovoi, I.B. Kononenko, V.B. Larionova, A.I. Saltanov, V.Yu. Sel’chuk,

DOI:

https://doi.org/10.21320/2500-2139-2015-8-2-185-190

For a long time, cachexia has been considered one of symptoms of cancer progression. The word cachexia is of Greek origin (kakos — bad and hexis — condition). This disorder is associated with a decrease in physical activity, reduced effectiveness of anticancer therapy, and decreased survival rates. The study of dissemination of malignancies demonstrated that cachexia is caused not only by the malignancy itself, but also by development of anorexia (loss of appetite) due to changes in humoral regulation of metabolic processes. Therefore, such condition of cancer patients should be called an anorexia-cachexia syndrome.

  • Anton Vladimirovich Snegovoi N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478 ; ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина», Каширское ш., д. 24, Москва, Российская Федерация, 115478
  • I.B. Kononenko N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478 ; ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина», Каширское ш., д. 24, Москва, Российская Федерация, 115478
  • V.B. Larionova N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478 ; ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина», Каширское ш., д. 24, Москва, Российская Федерация, 115478
  • A.I. Saltanov N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478 ; ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина», Каширское ш., д. 24, Москва, Российская Федерация, 115478
  • V.Yu. Sel’chuk N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478 ; ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина», Каширское ш., д. 24, Москва, Российская Федерация, 115478
  1. Кононенко И.Б., Ларионова В.Б., Манзюк Л.В. и др. Синдром анорексии-кахексии. В кн.: Практические рекомендации по лекарственному лечению злокачественных опухолей (RUSSCO). Под ред. В.М. Моисеенко. М.: Общество онкологов-химиотерапевтов, 2014. С. 399–402.
  2. [Kononenko IB, Larionova VB, Manzyuk LV, et al. Cahexia-anorexia syndrome. In: Moiseenko VM, ed. Prakticheskie rekomendatsii po lekarstvennomu lecheniyu zlokachestvennykh opukholei (RUSSCO). (Practical guidelines for drug therapy of malignancies (RUSSCO).) Moscow: Obshchestvo onkologov-khimioterapevtov Publ.; 2014. pp. 399–402. (In Russ)]
  3. DeVita VT. Jr, Lawrence TS, Rosenberg SA. Cancer: Principles and Practice of Oncology. 9th edition. Philadelphia: Lippincott Williams & Wilkins; 2011.
  4. Dewys WD, Begg C, Lavin PT, et al. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med. 1980;69(4):491–7. doi: 10.1016/s0149-2918(05)80001-3. DOI: https://doi.org/10.1016/S0149-2918(05)80001-3
  5. Del Fabbro E, Inui A, Strasser F. Cancer Cachexia. Pocket book for cancer supportive care. Springer Healthcare; 2012. DOI: https://doi.org/10.1007/978-1-910315-07-1
  6. Снеговой А.В. Школа «Поддерживающей терапии в онкологии». 2014. http://www.rosoncoweb.ru/events/2014/12/05/
  7. [Snegovoi AV. Maintenance Therapy in Oncology School; 2014. http://www.rosoncoweb.ru/events/2014/12/05/]
  8. Hamid RAH, Umbas R, Mochtar CA. Recent role of inflammation in prostate diseases: chemoprevention development opportunity. Acta Med Indones. 2011;43(1):59–65.
  9. Argiles JM, Busquets S, Garcia-Martonez C, Lopez-Soriano FJ. Mediators involved in the cancer anorexia-cachexia syndrome: past, present, and future. Nutrition. 2005;21(9):977–85. doi: 10.1016/j.nut.2005.02.003. DOI: https://doi.org/10.1016/j.nut.2005.02.003
  10. Materials of conference of the Multinational Association of Supportive Care in Cancer (MASCC), June 2014. J Sup Care Cancer. 2014;22(Suppl 1):28–31.
  11. Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489–95. doi: 10.1016/s1470-2045(10)70218-7. DOI: https://doi.org/10.1016/S1470-2045(10)70218-7
  12. Evans WJ, Morley JE, Argiles J, et al. Cachexia: a new definition. J Clin Nutr. 2008;27(6):793–9. doi: 10.1016/j.clnu.2008.06.013. DOI: https://doi.org/10.1016/j.clnu.2008.06.013
  13. Daley RJ, Canada T. Managing the cancer anorexia-cachexia syndrome: a pharmacologic review. Oncol Nutr Connect. 2004;12(4):1–6.
  14. Bosaeus I. Nutritional support in multimodal therapy for cancer cachexia. Sup Care Cancer. 2008;16(5):447–51. doi: 10.1007/s00520-007-0388-7. DOI: https://doi.org/10.1007/s00520-007-0388-7
  15. Thoresen L, Frykholm G, Lydersen S, et al. Nutritional status, cachexia and survival in patients with advanced colorectal carcinoma. Different assessment criteria for nutritional status provide unequal results. Clin Nutr. 2013;32(1):65–72. doi: 10.1016/j.clnu.2012.05.009. DOI: https://doi.org/10.1016/j.clnu.2012.05.009
  16. Baldwin C, Spiro A, McGough C, et al. Simple nutritional intervention in patients with advanced cancers of the gastrointestinal tract, non-small cell lung cancers or mesothelioma and weight loss receiving chemotherapy: a randomised controlled trial. J Hum Nutr Diet. 2011;24(5):431–40. doi: 10.1111/j.1365-277x.2011.01189.x. DOI: https://doi.org/10.1111/j.1365-277X.2011.01189.x
  17. Maltoni M, Nanni O, Scarpi E. High-dose progestins for the treatment of cancer anorexia-cachexia syndrome: A systematic review of randomised clinical trials. Ann Oncol. 2001;12(3):289–300. doi: 10.1023/a:1011156811739. DOI: https://doi.org/10.1023/A:1011156811739

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  • Anton Vladimirovich Snegovoi, PhD, N.N. Blokhin Russian Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478, ФГБНУ «Российский онкологический научный центр им. Н.Н. Блохина», Каширское ш., д. 24, Москва, Российская Федерация, 115478, e-mail: anvs2012@gmail.com

Published

01.04.2015

Issue

HEALTHCARE MANAGEMENT

How to Cite

Snegovoi A.V., Kononenko I.B., Larionova V.B., Saltanov A.I., Sel’chuk V.Y. Anorexia-Cachexia Syndrome in Cancer Patients. Clinical Oncohematology. Basic Research and Clinical Practice. 2015;8(2):185–190. doi:10.21320/2500-2139-2015-8-2-185-190.

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