Принципы патоморфологической дифференциальной диагностики миелодиспластических синдромов

Алла Михайловна Ковригина; С. А. Глинкина; В. В. Байков

doi:10.21320/2500-2139-2015-8-1-62-68

Principles of Pathomorphological Differential Diagnosis of Myelodysplastic Syndromes

Alla Mikhailovna Kovrigina, S.A. Glinkina, V.V. Baikov,

DOI:

https://doi.org/10.21320/2500-2139-2015-8-1-62-68

Abstract Authors References

The article dwells on the diagnosis of myelodysplastic syndromes (MDS) in bone marrow trephine biopsies. The paper describes problems of a complex approach to differential diagnostics of MDS and non-clonal/reactive changes in hematopoiesis. It is emphasized that clinical and laboratory data, as well as data on patient’s medical history should be submitted to a pathologist. The authors substantiate the algorithm for the morphological investigation of a bone marrow trephine bioptate, including evaluation of cellularity, stromal patterns, and morphological signs of dysplasia. The diagnostic value of histochemistry and immunohistochemistry is discussed.

Alla Mikhailovna Kovrigina Hematology Research Center, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167 ; ФГБУ «Гематологический научный центр» Минздрава России, Новый Зыковский пр-д, д. 4а, Москва, Российская Федерация, 125167
S.A. Glinkina Hematology Research Center, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167 ; ФГБУ «Гематологический научный центр» Минздрава России, Новый Зыковский пр-д, д. 4а, Москва, Российская Федерация, 125167
V.V. Baikov R.M. Gorbacheva Scientific Research Institute of Pediatric Hematology and Transplantation; Academician I.P. Pavlov First St. Petersburg State Medical University, 12 Rentgena str., Saint Petersburg, Russian Federation, 197022 ; НИИ детской онкологии, гематологии и трансплантологии им. Р.М. Горбачевой, Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, ул. Рентгена, д. 12, Санкт-Петербург, Российская Федерация, 197022

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Keywords:

myelodysplastic syndrome, bone marrow trephine biopsy, pathomorphology, differential diagnostics

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Alla Mikhailovna Kovrigina, PhD, Hematology Research Center, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167, ФГБУ «Гематологический научный центр» Минздрава России, Новый Зыковский пр-д, д. 4а, Москва, Российская Федерация, 125167, e-mail: kovrigina.alla@gmail.com

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01.01.2015

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Vol. 8 No. 1 (2015)

MYELOID MALIGNANCIES

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Kovrigina A.M., Glinkina S.A., Baikov V.V. Principles of Pathomorphological Differential Diagnosis of Myelodysplastic Syndromes. Clinical Oncohematology. Basic Research and Clinical Practice. 2015;8(1):62–68. doi:10.21320/2500-2139-2015-8-1-62-68.

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