Clinical and Prognostic Value of Molecular Markers of Diffuse Large B-Cell Lymphoma

S.M. Rastorguev, D.A. Koroleva, E.S. Boulygina, S.V. Tsygankova, N.G. Goncharov, O.S. Naraikin, N.G. Gabeeva, E.E. Zvonkov, A.V. Nedoluzhko,

DOI:

https://doi.org/10.21320/2500-2139-2019-12-1-95-100

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid tumor in adults which is associated with approximately 30–40 % of all non-Hodgkin’s lymphomas. Diagnostic criteria include diffuse growth of large anaplastic tumor cells, expression of В-cell markers, and a high proliferative index. Due to the development of molecular genetic technologies it became obvious that underlying cause of clinical diversity is a huge amount of genetic failures which determine epigenetic modification of gene expression, activation variability of certain signaling pathways, and immunological properties of tumor cells. The study and systemization of molecular markers present a significant trend in DLBCL diagnosis and treatment. This review discusses most important molecular markers and current view on their clinical value.

  • S.M. Rastorguev National Research Center “Kurchatov Institute”, 1 Akademika Kurchatova sq., Moscow, Russian Federation, 123182 ; ФГБУ «НИЦ “Курчатовский институт”», пл. Академика Курчатова, д. 1, Москва, Российская Федерация, 123182
  • D.A. Koroleva National Medical Hematology Research Center, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167 ; ФГБУ «НМИЦ гематологии» Минздрава России, Новый Зыковский пр-д, д. 4а, Москва, Российская Федерация, 125167
  • E.S. Boulygina National Research Center “Kurchatov Institute”, 1 Akademika Kurchatova sq., Moscow, Russian Federation, 123182 ; ФГБУ «НИЦ “Курчатовский институт”», пл. Академика Курчатова, д. 1, Москва, Российская Федерация, 123182
  • S.V. Tsygankova National Research Center “Kurchatov Institute”, 1 Akademika Kurchatova sq., Moscow, Russian Federation, 123182 ; ФГБУ «НИЦ “Курчатовский институт”», пл. Академика Курчатова, д. 1, Москва, Российская Федерация, 123182
  • N.G. Goncharov National Research Center “Kurchatov Institute”, 1 Akademika Kurchatova sq., Moscow, Russian Federation, 123182 ; ФГБУ «НИЦ “Курчатовский институт”», пл. Академика Курчатова, д. 1, Москва, Российская Федерация, 123182
  • O.S. Naraikin National Research Center “Kurchatov Institute”, 1 Akademika Kurchatova sq., Moscow, Russian Federation, 123182 ; ФГБУ «НИЦ “Курчатовский институт”», пл. Академика Курчатова, д. 1, Москва, Российская Федерация, 123182
  • N.G. Gabeeva National Medical Hematology Research Center, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167 ; ФГБУ «НМИЦ гематологии» Минздрава России, Новый Зыковский пр-д, д. 4а, Москва, Российская Федерация, 125167
  • E.E. Zvonkov National Medical Hematology Research Center, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167 ; ФГБУ «НМИЦ гематологии» Минздрава России, Новый Зыковский пр-д, д. 4а, Москва, Российская Федерация, 125167
  • A.V. Nedoluzhko National Research Center “Kurchatov Institute”, 1 Akademika Kurchatova sq., Moscow, Russian Federation, 123182 ; ФГБУ «НИЦ “Курчатовский институт”», пл. Академика Курчатова, д. 1, Москва, Российская Федерация, 123182
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Keywords:

lymphoma, DLBCL, B-cells, transcriptomics, gene expression, epigenomics, genomics

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Vol. 12 No. 1 (2019)
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Rastorguev S.M., Koroleva D.A., Boulygina E.S., et al. Clinical and Prognostic Value of Molecular Markers of Diffuse Large B-Cell Lymphoma. Clinical Oncohematology. Basic Research and Clinical Practice. 2019;12(1):95–100. doi:10.21320/2500-2139-2019-12-1-95-100.

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