Prognostic Value of the Degree of Tumor Tissue Infiltration by CD15-Positive Granulocytes in Nodular Sclerosis Classical Hodgkin’s Lymphoma

Elena Aleksandrovna Perfilova, D.A. D’yakonov, M.S. Minaev,

DOI:

https://doi.org/10.21320/2500-2139-2022-15-3-253-258

Classical Hodgkin’s lymphoma (cHL) nodular sclerosis type is one of the most common malignant lymphoproliferative diseases among younger people. The tumor is considered to be potentially curable. However, despite successful application of standard treatment methods, primary resistance and relapses occur. At present, many researchers focus on studying the value of tumor microenvironment in the prognosis of the course and progression of cHL, aiming at identifying new therapeutic targets. The present paper shows that the relative count of CD15-positive granulocytes in patients with favorable course of the disease is significantly lower than in therapy-refractory patients. The cut-off of tumor microenvironment cells expressing CD15 was 8 %. The data obtained provide the basis for determining prognostic value of CD15-positive granulocytes in nodular sclerosis cHL and presenting this cell pool as a potential therapeutic target.

  • Elena Aleksandrovna Perfilova Kirov Research Institute of Hematology and Transfusiology, 72 Krasnoarmeiskaya ul., Kirov, Russian Federation, 610027 ; ФГБУН «Кировский НИИ гематологии и переливания крови ФМБА», ул. Красноармейская, д. 72, Киров, Российская Федерация, 610027
  • D.A. D’yakonov Kirov Research Institute of Hematology and Transfusiology, 72 Krasnoarmeiskaya ul., Kirov, Russian Federation, 610027 ; ФГБУН «Кировский НИИ гематологии и переливания крови ФМБА», ул. Красноармейская, д. 72, Киров, Российская Федерация, 610027
  • M.S. Minaev Kirov Research Institute of Hematology and Transfusiology, 72 Krasnoarmeiskaya ul., Kirov, Russian Federation, 610027 ; ФГБУН «Кировский НИИ гематологии и переливания крови ФМБА», ул. Красноармейская, д. 72, Киров, Российская Федерация, 610027
  1. Демина Е.А., Тумян Г.С., Моисеева Т.Н. Лимфома Ходжкина. Клинические рекомендации. Современная онкология. 2020;22(2):6–33.
  2. [Demina EA, Tumyan GS, Moiseeva TN. Hodgkin’s lymphoma. Clinical guidelines. Sovremennaya onkologiya. 2020;22(2):6–33. (In Russ)]
  3. Российские клинические рекомендации по диагностике и лечению лимфопролиферативных заболеваний. Под ред. И.В. Поддубной, В.Г. Савченко. М.: Буки Веди, 2018. 356 с.
  4. [Poddubnaya IV, Savchenko VG, eds. Rossiiskie klinicheskie rekomendatsii po diagnostike i lecheniyu limfoproliferativnykh zabolevanii. (Russian clinical guidelines on diagnosis and treatment of lymphoproliferative disorders.) Moscow: Buki Vedi Publ.; 2018. 356 р. (In Russ)]
  5. Мочкин Н.Е., Н.Е., Саржевский В.О., Дубинина Ю.Н. и др. Результаты лечения классической лимфомы Ходжкина, включающего высокодозную химиотерапию с трансплантацией аутологичных гемопоэтических стволовых клеток, в НМХЦ им. Н.И. Пирогова. Клиническая онкогематология. 2018;11(3):234–40. doi: 10.21320/2500-2139-2018-11-3-234-240. DOI: https://doi.org/10.21320/2500-2139-2018-11-3-234-240
  6. [Mochkin NE, Sarzhevskii VO, Dubinina YuN, et. al. Outcome of Classical Hodgkin’s Lymphoma Treatment Based on High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation: The Experience in the NI Pirogov Russian National Medical Center of Surgery. Clinical oncohematology. 2018;11(3):234–40. doi: 10.21320/2500-2139-2018-11-3-234-240. (In Russ)] DOI: https://doi.org/10.21320/2500-2139-2018-11-3-234-240
  7. Беляева Е.С., Сусулева Н.А., Валиев Т.Т. Значение интенсивной химиотерапии для лечения детей с распространенными стадиями лимфомы Ходжкина. РМЖ. Мать и дитя. 2020;3(2):149–54. doi: 10.32364/2618-8430-2020-3-2-149-154. DOI: https://doi.org/10.32364/2618-8430-2020-3-2-149-154
  8. [Belyaeva ES, Susuleva NA, Valiev TT. The importance of intensive chemotherapy for advanced Hodgkin lymphoma in children. Russian Journal of Woman and Child Health. 2020;3(2):149–54. doi: 10.32364/2618-8430-2020-3-2-149-154. (In Russ)] DOI: https://doi.org/10.32364/2618-8430-2020-3-2-149-154
  9. Олейник Е.К., Шибаев М.И., Игнатьев К.С. Микроокружение опухоли: формирование иммунного профиля. Медицинская иммунология. 2020;22(2):207–20.
  10. [Oleinik EK, Shibaev MI, Ignat’ev KS. Tumor microenvironment: the formation of the immune profile. Meditsinskaya immunologiya. 2020;22(2):207–20. (In Russ)]
  11. Sionov RV, Fridlender ZG, Granot Z. The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment. Cancer Microenviron. 2015;8(3):125–58. doi: 10.1007/s12307-014-0147-5. DOI: https://doi.org/10.1007/s12307-014-0147-5
  12. Uribe-Querol E, Rosales C. Neutrophils in Cancer: Two Sides of the Same Coin. J Immunol Res. 2015;2015:983698. doi: 10.1155/2015/983698. DOI: https://doi.org/10.1155/2015/983698
  13. Лисяный Н.И., Лисяный А.А. Нейтрофилы и онкогенез. Клиническая онкология. 2018;8(1):40–5.
  14. [Lisyanyi NI, Lisyanyi AA. Neutrophils and oncogenesis. Klinicheskaya onkologiya. 2018;8(1):40–5. (In Russ)]
  15. Потапнев М.П., Гущина Л.М., Мороз Л.А. Фенотипическая и функциональная гетерогенность субпопуляций нейтрофилов в норме и при патологии. Иммунология. 2019;5:84–96.
  16. [Potapnev MP, Gushchina LM, Moroz LA. Phenotypic and functional heterogeneity of neutrophil subpopulations in norm and pathology. Immunologiya. 2019;5:84–96. (In Russ)]
  17. Слуханчук Е.В. NETs и онкологический процесс. Акушерство, гинекология и репродукция. 2021;15(1):107–16. doi: 17749/2313-7347/ob.gyn.rep.2021.204.
  18. [Slukhanchuk EV. NETs and oncologic process. Akusherstvo, ginekologia i reprodukcia. 2021;15(1):107–16. doi: 10.17749/2313-7347/ob.gyn.rep.2021.204. (In Russ)] DOI: https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.204
  19. Fridlender ZG, Albelda SM. Tumor-associated neutrophils: Friend or foe? Carcinogenesis. 2012;33(5):949–55. doi: 10.1093/carcin/bgs123. DOI: https://doi.org/10.1093/carcin/bgs123
  20. Francischetti IMB, Alejo JC, Sivanandham R, et al. Neutrophil and Eosinophil Extracellular Traps in Hodgkin Lymphoma. HemaSphere. 2021;5(9):e633. doi: 10.1097/HS9.0000000000000633. DOI: https://doi.org/10.1097/HS9.0000000000000633
  21. Romano A, Pavoni C, Di Raimondo F, et al. The neutrophil to lymphocyte ratio (NLR) and the presence of large nodal mass are independent predictors of early response: A subanalysis of the prospective phase II PET-2-adapted HD0607 trial. Cancer Med. 2020;9(23):8735–46. doi: 10.1002/cam4.3396. DOI: https://doi.org/10.1002/cam4.3396
  22. Manfroi B, Moreaux J, Righini C, et al. Tumor-associated neutrophils correlate with poor prognosis in diffuse large B-cell lymphoma patients. Blood Cancer J. 2018;8(7):66. doi: 10.1038/s41408-018-0099-y. DOI: https://doi.org/10.1038/s41408-018-0099-y

Keywords:

classical Hodgkin’s lymphoma, nodular sclerosis, CD15 granulocytes, tumor microenvironment

License

Copyright (c) 2022 Clinical Oncohematology

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Downloads

Download data is not yet available.

For Contact

  • Elena Aleksandrovna Perfilova, PhD in Veterinary Medicine, Kirov Research Institute of Hematology and Transfusiology, 72 Krasnoarmeiskaya ul., Kirov, Russian Federation, 610027, ФГБУН «Кировский НИИ гематологии и переливания крови ФМБА», ул. Красноармейская, д. 72, Киров, Российская Федерация, 610027, e-mail: lperf78@gmail.com

Downloads

Published

01.07.2022

Issue

Vol. 15 No. 3 (2022)
LYMPHOID TUMORS

How to Cite

Perfilova E.A., D’yakonov D.A., Minaev M.S. Prognostic Value of the Degree of Tumor Tissue Infiltration by CD15-Positive Granulocytes in Nodular Sclerosis Classical Hodgkin’s Lymphoma. Clinical Oncohematology. Basic Research and Clinical Practice. 2022;15(3):253–258. doi:10.21320/2500-2139-2022-15-3-253-258.

Most read articles by the same author(s)