The Use of Ibrutinib in Refractory Chronic Lymphocytic Leukemia and in High-Risk Patients

LYMPHOID TUMORS , , ,

NV Kurkina1,2, EA Repina1, NN Mashnina2

1 NP Ogarev Mordovia National Research State University, 68 Bol’shevistskaya str., Saransk, Republic of Mordovia, Russian Federation, 430032

2 Republican Clinical Hospital No. 4, 32 Ul’yanova str., Saransk, Republic of Mordovia, Russian Federation, 430032

For correspondence: Nadezhda Viktorovna Kurkina, MD, PhD, 68 Bol’shevistskaya str., Saransk, Republic of Mordovia, Russian Federation, 430032; e-mail: nadya.kurckina@yandex.ru

For citation: Kurkina NV, Repina EA, Mashnina NN. The Use of Ibrutinib in Refractory Chronic Lymphocytic Leukemia and in High-Risk Patients. Clinical oncohematology. 2019;12(3):278–81 (In Russ).

doi: 10.21320/2500-2139-2019-12-3-278-281

ABSTRACT

Despite advances in chemo-immunotherapy of chronic lymphocytic leukemia, a choice of therapy is a frequent challenge in patients with a refractory form of the disease, autoimmune hemolytic complications, and also in high-risk patients with cytogenetic changes. The use of ibrutinib, one of Bruton’s tyrosine kinase inhibitors, allows to overcome the resistance to anticancer therapy without adverse effects on patients’ quality of life.

Keywords: chronic lymphocytic leukemia, chemo-immunotherapy, ibrutinib, refractoriness, relapse.

Received: January 21, 2018

Accepted: May 10, 2019

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