Rituximab (MabThera) for subcutaneous administration, new opportunities well-studied drug

CLINICAL PRESENTATION, DIAGNOSIS, AND MANAGEMENT OF LYMPHOID MALIGNANCIES ,

G.S. Tumyan

N.N. Blokhin Russian Cancer Research Center of RAMS, Moscow, Russian Federation

ABSTRACT

The current concept of anticancer therapy optimization means reduction of health care costs, decreased toxicity with the same or greater efficacy of the administered drug, and, as the result, more comfortable and convenient management of cancer patients. The new formulation of Rituximab (Mabthera) for subcutaneous (SC) administration meets all above criteria. The clinical studies of this drug demonstrate non-inferiority of the fixed dose 1400 mg SC compared to the approved dose of 375 mg/m2 intravenously. Mabthera SC shows the safety profile similar to the formulation for intravenous administration and makes the delivery of the drug faster (mean SC injection time = 10 minutes), safer, and more convenient for patients.

Keywords: Mabthera, formulation for subcutaneous administration.

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