New markers (CD160, CD200, and LAIR-1) in diagnosis of B-cell lymphoproliferative disorders

DIAGNOSIS AND TREATMENT OF LYMPHOID TUMORS , ,

S.A. Lugovskaya1, D.G. Kisilichina1, M.E. Pochtar1, E.V. Naumova1, E.A. Nikitin2, L.S. Al-Radi2

1-Russian Medical Academy for Postgraduate Education of Ministry of Health, Moscow, Russian Federation

2-FSBI «Haematological Research Center» Russian Ministry of Health, Moscow, Russian Federation

ABSTRACT

Flow cytometry is used in diagnosis and classification of B-cell lymphoproliferative disorders, measuring expression level of target antigen and monitoring of minimal residual disease. Immunological phenotype of tumor B cells is not always in accord with classical characteristic and it makes complicated the interpretation of data, and therefore there is a need to find additional informative markers. Using new monoclonal antibodies to CD160, CD200 and LAIR-1 enhances the diagnostic capabilities of flow cytometry.

Keywords: B-cell lymphoproliferative disorders, markers CD160, CD200, LAIR-1, multiparameter flow cytometry.

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