Mechanism of Low Hemolytic Activity of Alkyl Type Nonphosphorous Cationic Glycerolipids: Study on Model Membranes

EXPERIMENTAL STUDIES , , , ,

A.A. Markova1, S.A. Okorochenkov2, N.V. Plyavnik3, A.A. Shtil’1

1 N.N. Blokhin Russian Cancer Research Center of RAMS, Moscow, Russian Federation

2 Institute of Molecular and Translational Medicine, Palacky University, Czech Republiс

3 M.V. Lomonosov Moscow State University of Fine Chemical Technologies, Moscow, Russian Federation

For citation: Markova A.A., Okorochenkov S.A., Plyavnik N.V., Shtil’ A.A. Mechanism of Low Hemolytic Activity of Alkyl Type Nonphosphorous Cationic Glycerolipids: A Study on Model Membranes. Klin. onkogematol. 2014; 7(3): 278–81 (In Russ.).

ABSTRACT

Nonphosphorous alkyl cationic glycerolipids cause death of tumor cells with minimal damage of erythrocytes. In this article we demonstrate, that low hemolytic activity of these compounds can be explained by their weak ability to damage the integrity of liposomes whose composition models that of cell membranes. Poor hemolytic activity makes non-phosphorous alkyl cationic glycerolipids potentially advantageous over the hemolytic, phosphorus containing lipid drug edelfosine.

Keywords: non-phosphorous cationic alkyl glycerolipids, edelfosine, artificial liposomes, carboxyfluorescein, hemolysis.

Address correspondence to: alenmark25@gmail.com

Accepted: May 05, 2014

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