Local Immunity in Hematological Patients with Oropharyngeal Candidiasis

INFECTIONS IN ONCOHEMATOLOGY , , ,

E.Yu. Danilovа, N.V. Shabashova, E.V. Frolova, A.E. Uchevatkina, L.V. Filippova

I.I. Mechnikov North-West State Medical University under the Ministry of Health of Russia, 41 Kirochnaya str., Saint Petersburg, Russian Federation, 191015

For correspondence: Evgeniya Yur’evna Danilova, graduate student in the Department of Clinical Mycology, 41 Kirochnaya str., Saint Petersburg, Russian Federation, 191015; Tel.: +7(812)303-51-41; e-mail: danilovaimmuno@yandex.ru

For citation: Danilova EYu, Shabashova NV, Frolova EV, et al. Local Immunity in Hematological Patients with Oropharyngeal Candidiasis. Clinical oncohematology. 2015;8(4):436–441 (In Russ).

DOI: 10.21320/2500-2139-2015-8-4-436-441

ABSTRACT

Aim. To evaluate the incidence of oropharyngeal candidiasis (OFC) among oncohematological patients depending on the type of the malignancy and anti-tumor treatment, as well as to assess key cytokine levels in saliva samples.

Methods. 430 patients were enrolled in the study, and 85 samples of saliva were collected from patients with OFC (n = 38) and without it. The control group consisted of 19 healthy volunteers.

Results. The OFC incidence was 9 % and it did not depend on the immunomorphological type of the malignancy and the type of chemotherapy. Before the anti-tumor treatment, TNF-a, IL-17 and G-CSF levels in saliva samples were elevated in all patients. The TNF-a (p < 0.05) synthesis was decreased after the anti-tumor treatment. Besides, a tendency to reduced G-CSF and IL-17 production was found. In patients with OFC, MCP-1, IL-17, IFN-g levels were decreased.

Conclusion. In OFC patients with hematopoietic and lymphoid tissue malignancies, impairment of basic types of local antifungal protection was found.

Keywords: oropharyngeal candidiasis, hematopoietic and lymphoid tissue malignancies, local immunity, Candida spp.

Received: July 1, 2015

Accepted: November 9, 2015

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