Listeria monocytogenes Meningitis in a Female Patient with Primary Mediastinal (Thymic) Large B-Cell Lymphoma: A Case Report

AM Pronina1, SV Zhuravleva1, GS Yunaev1, IZ Zavodnova1, IA Kurmukov2

1 NN Blokhin National Medical Cancer Research Center, 24 Kashirskoye sh., Moscow, Russian Federation, 115478

2 AS Loginov Moscow Clinical Scientific Center, 89 Entuziastov sh., Moscow, Russian Federation, 111123

For correspondence: Ildar Anvarovich Kurmukov, MD, PhD, 89 Entuziastov sh., Moscow, Russian Federation, 111123; e-mail:

For citation: Pronina AM, Zhuravleva SV, Yunaev GS, et al. Listeria monocytogenes Meningitis in a Female Patient with Primary Mediastinal (Thymic) Large B-Cell Lymphoma: A Case Report. Clinical oncohematology. 2020;13(4):420–5. (In Russ).

DOI: 10.21320/2500-2139-2020-13-4-420-425


Listeriosis with severe clinical manifestations in the form of bacteraemia, sepsis, and meningitis/meningoencephalitis is a rare but a challenging issue of supportive care in oncohematology. Early diagnosis of listeriosis, as well as any other infection, is hampered by severe general manifestations of a malignant lymphoproliferative disorder or tumor complications and its treatment. In patients with pronounced decreased drug-induced immunity listeriosis is usually characterized as a rapidly developing and, as a rule, severe disease with high immediate mortality. The present article offers a case report of severe listeria infection in a female patient admitted to the intensive care unit for the treatment of primary mediastinal (thymic) large B-cell lymphoma with a large tumor mass in anterior mediastinum complicated by mediastinal and superior vena cava compression syndromes.

Keywords: primary mediastinal (thymic) large B-cell lymphoma, listeriosis, meningitis, supportive care.

Received: June 14, 2020

Accepted: September 17, 2020

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