Importance of biochemical studies of brain natriuretic peptide in patients with diffuse large B-cell lymphoma

LABORATORY DIAGNOSIS , , ,

M.O. Yegorova, Ye.N. Komolova, and S.Ye. Samsonova

Hematology Research Center, RF Ministry of Health, Moscow, Russian Federation

ABSTRACT

In this study, we measured the levels of the brain natriuretic peptide (BNP) in the blood of patients with diffuse large B-cell lymphoma (DBCL) before and after polychemotherapy. The study included 10 patients: 6 males and 4 females at the age of 39 to 63 (mean age = 51 ± 12). The control group consisted of 20 virtually healthy donors. It was shown that measurements of BNP plasma levels in DBCL could identify the patients with the high risk of heart failure. Screening tests with determination of BNP levels can influence the choice of chemotherapy for DBCL.

Keywords: diffuse large B-cell lymphoma, chemotherapy, BNP, myocardial infarction, congestive left ventricular heart failure.

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