Diagnosis of EBV-Associated Inflammatory Pseudotumor in the Spleen: A Case Report

DI Chebotarev, AM Kovrigina, SM Korzhova, KI Danishyan, KR Sabirov

National Medical Hematology Research Center, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167

For correspondence: Dmitrii Il’ich Chebotarev, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167; Tel.: +7(916)091-27-09; e-mail: chebadmitry@gmail.com

For citation: Chebotarev DI, Kovrigina AM, Korzhova SM, et al. Diagnosis of EBV-Associated Inflammatory Pseudotumor in the Spleen: A Case Report. Clinical oncohematology 2019;12(4):428–33 (In Russ).

DOI: 1021320/2500-2139-2019-12-4-428-433


ABSTRACT

The paper focuses on Epstein-Barr virus (EBV)-associated inflammatory pseudotumor in the spleen, an extremely rare disease which so far remained undefined in the Russian literature. The morphology of it is not characterized by any specific features and is represented by a spindle-cell component with pronounced inflammatory infiltration which complicates differential diagnosis. Previously this nosology was regarded within a group of the so-called inflammatory pseudotumors due to the similarity of the clinical course and radiological presentation with tumor processes. Today the term “inflammatory pseudotumor” is considered obsolete, since as pathogenesis was being studied within this disease group, the individual forms with similar morphology and different histogenesis were identified. Differential diagnosis in the context of additional diagnostic techniques is based in such cases on a wide range of reactive states, benign and malignant tumors.

Keywords: inflammatory pseudotumor, inflammatory myofibroblastic pseudotumor, EBV-associated inflammatory pseudotumor in the spleen, IgG4-associated diseases, variant of follicular dendritic cell sarcoma similar to inflammatory pseudotumor.

Received: May 19, 2019

Accepted: September 15, 2019

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REFERENCES

  1. Bhaskar S, Levin M, Frish J. Plasma cell granuloma of periodontal tissues. Report of 45 cases. Periodontics. 1968;6(6):272–6.

  2. Mason WE, Keats TE, Baker GF. Inflammatory pseudotumor of the lung. Radiology. 1963;81(5):824–7. doi: 10.1148/81.5.824.

  3. Herczeg E, Weissberg D, Almog C, Pajewski M. Inflammatory fibrous histiocytoma of the bronchus. Chest. 1978;73(5):669–70. doi: 10.1378/chest.73.5.669.

  4. Poleksic S, Kalwaic HJ, Bialas RF. Benign atypical fibroxanthoma or a malignant tumor? A warning. Case reports. Plast Reconstr Surg. 1976;58(4):501–5. doi: 10.1097/00006534-197610000-00024.

  5. Forster R, Ruschoff J, Kleinsorge F. Retroperitoneal xanthofibrogranulomatosis. RoFo. 1989;151(12):688–91. doi: 10.1055/s-2008-1047268.

  6. Greenberg SD, Jenkins DE. Xanthomatous inflammatory pseudotumor of the lung. South Med J. 1975;68(6):754–6. doi: 10.1097/00007611-197506000-00025.

  7. Pisciotto PT, Gray GF Jr, Miller DR. Abdominal plasma cell pseudotumor. J Pediatr. 1978;93(4):628–30. doi: 10.1016/s0022-3476(78)80903-2.

  8. Sherwin RP, Kern WH, Jones JC. Solitary mast cell granuloma (histiocytoma) of the lung; a histopathologic, tissue culture and time-lapse cinematographic study. Cancer. 1965;18(5):634–41. doi: 10.1002/1097-0142(196505)18:5%3C634::aid-cncr2820180512%3E3.0.co;2-k.

  9. Coffin CM, Dehner LP, Meis-Kindblom JM. Inflammatory myofibroblastic tumor, inflammatory fibrosarcoma, and related lesions: an historical review with differential diagnostic considerations. Semin Diagn Pathol. 1998;15(2):102–10.

  10. Brunn H. Two interesting benign lung tumours of contradictory histopathology: remarks on the necessity for maintaining the chest tumour registry. J Thorac Cardiovasc. 1939;9:119–31.

  11. Umiker WO, Iverson LC. Post inflammatory tumor of the lung: report of four cases simulating xanthoma, fibroma or plasma cell granuloma. J Thorac Surg. 1954;28(1):55–63.

  12. Lakshmana DN, Beverley N, Stephanie SS, et al. Inflammatory Pseudotumor. RadioGraphics. 2003;23(3):719–29. doi: 10.1148/rg.233025073.

  13. Patnana M, Sevrukov AB, Elsayes KM, et al. Inflammatory Pseudotumor: The Great Mimicker. Am J Roentgenol. 2012;198(3):W217–W227. doi. 10.1111/j.1440-1827.2010.02556.x.

  14. Bosse K, Ott C, Biegner T, et al. 23-year-old female with an inflammatory myofibroblastic tumour of the breast: a case report and a review of the literature. Geburtshilfe Frauenheilkunde. 2014;74(02):167–70. doi: 10.1055/s-0033-1360185.

  15. Santaolalla-Montoya F, Ereno C, Zabala A, et al. Inflammatory myofibroblastic tumor of the temporal bone: a histologically nonmalignant lesion with fatal outcome. Skull Base. 2008;18(05):339–43. doi: 10.1055/s-0028-1086060.

  16. Oh JH, Yim JH, Yoon BW, et al. Inflammatory pseudotumor in the mandible. J Craniofac Surg. 2008;19(6):1552–3. doi: 10.1097/scs.0b013e318188a2e9.

  17. Williamson RA, Paueksakon P, Coker NJ. Inflammatory pseudotumor of the temporal bone. Otol Neurotol. 2003;24(5):818–82. doi: 10.1097/00129492-200309000-00021.

  18. Yuan XP, Li CX, Cao Y, et al. Inflammatory myofibroblastic tumour of the maxillary sinus: CT and MRI findings. Clin Radiol. 2012;67(12): e53–e57. doi: 10.1016/j.crad.2012.08.002.

  19. Masciocchi C, Lanni G, Conti L, et al. Soft-tissue inflammatory myofibroblastic tumors (IMTs) of the limbs: Potential and limits of diagnostic imaging. Skelet Radiol. 2012;41(6):643–9. doi: 10.1007/s00256-011-1263-7.

  20. Lin J, Liu H, Zhuang Y, et al. Inflammatory myofibroblastic tumor of the thigh without bone involvement: a case report. World J Surg Oncol. 2014;12(1):208. doi: 10.1186/1477-7819-12-208.

  21. Sanders BM, West KW, Gingalewski C, et al. Inflammatory pseudotumor of the alimentary tract: clinical and surgical experience. J Pediatr Surg. 2001;36(1):169–73. doi: 10.1053/jpsu.2001.20045.

  22. Gong S, Auer I, Duggal R, et al. Epstein-Barr virus-associated inflammatory pseudotumor presenting as a colonic mass. Hum Pathol. 2015;46(12):1956–61. doi: 10.1016/j.humpath.2015.08.011.

  23. Rosenbaum L, Fekrazad MH, Rabinowitz I, Vasef MA. Epstein-Barr virus-associated inflammatory pseudotumor of the spleen: report of two cases and review of the literature. J Hematop. 2009;2(2):127–31. doi: 10.1007/s12308-009-0030-3.

  24. Kim HJ, Kim JE, Kang GH, et al. Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor of the Spleen with Extensive Histiocytic Granulomas and Necrosis: A Case Report and Literature Review. Korean J Pathol. 2013;47(6):599–602. doi: 10.4132/KoreanJPathol.2013.47.6.599.

  25. Cook JR, Dehner LP, Collins MH, et al. Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. Am J Surg Pathol. 2001;25(11):1364–71. doi: 10.1097/00000478-200111000-00003.

  26. Lawrence B, Perez-Atayde A, Hibbard MK, et al. TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. Am J Pathol. 2000;157(2):377–84. doi: 10.1016/S0002-9440(10)64550-6.

  27. Della-Torre E, Lanzillotta M, Doglioni C. Immunology of IgG4-related disease. Clin Exp Immunol. 2015;181(2):191–206. doi: 10.1111/cei.12641.

  28. Lu Y, Li L, Bhat R, Hou JS. IgG4-Related Lesion in Spleen: Sclerosing Angiomatoid Nodular Transformation of the Spleen. Am J Clin Pathol. 2018;150(Suppl 1):S93. doi: 10.1093/ajcp/aqy097.223.

  29. Патологическая анатомия: атлас. Под ред. О.В. Зайратьянца. М.: ГЭОТАР-Медиа, 2012. 960 с.

    [Zairat’yants OV, ed. Patologicheskaya anatomiya: atlas. (Atlas of anatomic pathology.) Moscow: GEOTAR-Media Publ.; 960 p. (In Russ)]