Биспецифические антитела в клинике и клинических исследованиях (обзор литературы)

О.Н. Солопова, В.А. Мисюрин

ФГБУ «НМИЦ онкологии им. Н.Н. Блохина» Минздрава России, Каширское ш., д. 24, Москва, Российская Федерация, 115478

Для переписки: Всеволод Андреевич Мисюрин, канд. биол. наук, Каширское ш., д. 24, Moсква, Российская Федерация, 115478; тел. +7(985)436-30-19; e-mail: vsevolod.misyurin@gmail.com

Для цитирования: Солопова О.Н., Мисюрин В.А. Биспецифические антитела в клинике и клинических исследованиях (обзор литературы). Клиническая онкогематология. 2019;12(2):125–44.

DOI: 10.21320/2500-2139-2019-12-2-125-144


РЕФЕРАТ

Лечебные моноклональные антитела давно уже стали важным инструментом в руках врачей разных специальностей, прежде всего онкологов. Появление биспецифических антител открыло новые горизонты для лечения рака, стало возможным привлечение собственного иммунитета пациента к борьбе с опухолью. В данном обзоре рассматриваются все форматы и стратегии, использованные при разработке биспецифических антител, дошедших до стадии клинических исследований, а также доступные результаты этих клинических исследований.

Ключевые слова: биспецифические антитела, блинатумомаб, катумаксомаб, эмицизумаб, клиническое исследование.

Получено: 13 августа 2018 г.

Принято в печать: 22 января 2019 г.

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