легочная токсичность

Легочные осложнения высокодозной химиотерапии и аутологичной трансплантации костного мозга при онкогематологических заболеваниях

ОСЛОЖНЕНИЯ ПРОТИВООПУХОЛЕВОГО ЛЕЧЕНИЯ , ,

В.О. Саржевский, В.Я. Мельниченко, В.П. Тюрин

ФГБУ «Национальный медико-хирургический центр им. Н.И. Пирогова» МЗ РФ, Москва, Российская Федерация

РЕФЕРАТ

В обзоре представлены современные данные о легочных осложнениях высокодозной химиотерапии и аутологичной трансплантации костного мозга (периферических гемопоэтических стволовых клеток) у пациентов с онкогематологическими заболеваниями. Представлена подробная информация о методах исследования для оценки легочной токсичности, патогенетических и клинических особенностях легочных осложнений на всех этапах проведения трансплантации (ранняя легочная токсичность) и в более поздние сроки после окончания лечения (поздняя легочная токсичность). Приведены подходы к профилактике и лечению легочных осложнений у данной категории больных.

Ключевые слова: высокодозная химиотерапия, аутологичная трансплантация костного мозга, легочная токсичность.

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