Chronic Lymphocytic Leukemia in Blood Relatives: Two Case Reports of Male Siblings

AUTOIMMUNE THROMBOCYTOPENIA ,

NV Kurkina1,2, EA Repina1

1 NP Ogarev National Research Mordovia State University, 68 Bolshevistskaya str., Saransk, Russian Federation, 430005

2 Republican Clinical Hospital No. 4, 32 Ul’yanova str., Saransk, Russian Federation, 430032

For correspondence: Nadezhda Viktorovna Kurkina, MD, PhD, 32 Ul’yanova str., Saransk, Russian Federation, 430032; e-mail: nadya.kurckina@yandex.ru

For citation: Kurkina NV, Repina EA. Chronic Lymphocytic Leukemia in Blood Relatives: Two Case Reports of Male Siblings. Clinical oncohematology. 2021;14(1):69–72. (In Russ).

DOI: 10.21320/2500-2139-2021-14-1-69-72

ABSTRACT

In recent years there are more and more evidences for a hereditary factor in malignant lymphoproliferative disorders. Various lymphoid tumors are diagnosed in blood relatives. This is most frequently observed in chronic lymphocytic leukemia: 13.3 % vs. 8.8 % in non-Hodgkin’s lymphoma and 5.9 % in Hodgkin’s lymphoma. This paper presents two case reports of chronic lymphocytic leukemia in blood relatives (male siblings). Besides, in one of them the efficacy of targeted therapy with ibrutinib is estimated.

Keywords: chronic lymphocytic leukemia, heredity, ibrutinib, refractoriness, relapse.

Received: June 25, 2020

Accepted: November 6, 2020

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Статистика Plumx английский

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