A Case of M-Paraprotein-Associated Polyneuropathy with Stable Response to Rituximab Therapy

VG Potapenko1,3, VN Kiselev2

1 Municipal Clinical Hospital No. 31, 3 Dinamo pr-t, Saint Petersburg, Russian Federation, 197110

2 AM Nikiforov Russian Center of Emergency and Radiation Medicine, 4/2 Akademika Lebedeva str., Saint Petersburg, Russian Federation, 194044

3 IP Pavlov First Saint Petersburg State Medical University, 6/8 L’va Tolstogo str., Saint Petersburg, Russian Federation, 197022

For correspondence: Vsevolod Gennad’evich Potapenko, 3 Dinamo pr-t, Saint Petersburg, Russian Federation, 197110; Tel.: +7(905)284-51-38; e-mail: potapenko.vsevolod@mail.ru

For citation: Potapenko VG, Kiselev VN. A Case of M-Paraprotein-Associated Polyneuropathy with Stable Response to Rituximab Therapy. Clinical oncohematology. 2019;12(4):434–7 (In Russ).

DOI: 10.21320/2500-2139-2019-12-4-434-437


Monoclonal gammopathy of undetermined significance is diagnosed on the basis of an extensive search for a diagnostic reason as paraprotein secretion occurs in different diseases. One of polyneuropathies associated with M-paraproteinemia is anti-MAG demyelinating polyneuropathy (AMDP). The first-line treatment of this disease is based on prednisolone, and intravenous immunoglobulin. The second-line therapy of treatment-resistant patients is not determined. We report a case of a female patient with AMDP who received prednisolone, azathioprine, and plasmapheresis; however, stable response was reached only after the use of rituximab.

Keywords: paraprotein, monoclonal gammopathy of undetermined significance (MGUS), myelin-associated glycoprotein (MAG), polyneuropathy, rituximab.

Received: January 22, 2019

Accepted: September 5, 2019

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