A Case of Hairy Cell Leukemia Diagnosed Simultaneously with Lymphoplasmacytic Lymphoma by Anti-CD Antibody Microarray Method

LYMPHOID TUMORS , , , , ,

AN Khvastunova1,2, LS Al-Radi3, OS Fedyanina1,2, SA Lugovskaya4, SA Kuznetsova1,2

1 Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, 1 Samory Mashela str., Moscow, Russian Federation, 117997

2 Center for Theoretical Problems of Physicochemical Pharmacology, 4 Kosygina str., Moscow, Russian Federation, 119991

3 National Medical Hematology Research Center, 4а Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167

4 Russian Medical Academy of Postgraduate Education, 2/1 Barrikadnaya str., Moscow, Russian Federation, 1125993

For correspondence: Alina Nikolaevna Khvastunova, PhD in Biology, 1 Samory Mashela str., Moscow, Russian Federation, 117997; Tel.: +7(495)287-65-70; e-mail: alina_shunina@mail.ru

For citation: Khvastunova AN, Al-Radi LS, Fedyanina OS, et al. A Case of Hairy Cell Leukemia Diagnosed Simultaneously with Lymphoplasmacytic Lymphoma by Anti-CD Antibody Microarray Method. Clinical oncohematology. 2019;12(3):243–6 (In Russ).

doi: 10.21320/2500-2139-2019-12-3-243-246

ABSTRACT

The paper deals with a combined case of hairy cell leukemia and lymphoplasmacytic lymphoma with IgMκ paraprotein secretion. The use of anti-CD antibody microarray enabled the simultaneous assessment of immunophenotype as well as morphological and cytochemical analysis. Small populations of hairy (3 % of total lymphocyte count) and plasma (2 %) cells including Mott cells (0.2 %) were found in the peripheral blood of a patient with leukopenia. The results obtained by the anti-CD antibody microarray method speeded up provisional diagnosis which was later confirmed by standard diagnostic methods.

Keywords: anti-CD antibody microarray, hairy cell leukemia, lymphoplasmacytic lymphoma, hairy cells, plasma cells, Mott cells.

Received: November 12, 2018

Accepted: May 2, 2019

Read in PDF 

REFERENCES

  1. Khvastunova AN, Kuznetsova SA, Al-Radi LS, et al. Anti-CD antibody microarray for human leukocyte morphology examination allows analyzing rare cell populations and suggesting preliminary diagnosis in leukemia. Sci Rep. 2015;5(1):12573. doi: 10.1038/srep12573.

  2. Хвастунова А.Н., Аль-Ради Л.С., Капранов Н.М. и др. Использование клеточного биочипа в диагностике волосатоклеточного лейкоза. Онкогематология. 2015;10(1):37–45. doi: 10.17650/1818-8346-2015-1-37-45.

    [Khvastunova AN, Al-Radi LS, Kapranov NM, et al. Cell-binding microarray application in diagnosis of hairy cell leukemia. Oncohematology. 2015;10(1):37–45. doi: 10.17650/1818-8346-2015-1-37-45. (In Russ)]

  3. Khvastunova AN, Al‐Radi LS, Fedyanina OS, Kuznetsova SA. Simultaneous finding of chronic lymphocytic leukemia and residual hairy cell leukemia using a lymphocyte‐binding anti‐CD antibody microarray. Clin Case Rep. 2018;6(4):753–5. doi: 10.1002/ccr3.1416.

  4. Bain BJ. Leukemia Diagnosis. 4th edition. Singapore: Blackwell Publishing; 2010. doi: 10.1002/9781444318470.

  5. Луговская С.А., Почтарь М.Е. Гематологический атлас. М. – Тверь: Триада, 2011. 368 с.

    [Lugovskaya SA, Pochtar ME. Gematologicheskii atlas. (Hematology atlas.) Moscow – Tver: Triada Publ.; 2011. 368 р. (In Russ)]

  6. Shao H, Calvo KR, Gronborg M, et al. Distinguishing hairy cell leukemia variant from hairy cell leukemia: Development and validation of diagnostic criteria. Leuk Res. 2013;37(4):401–9. doi: 10.1016/j.leukres.2012.11.021.

  7. Robak T. Hairy-cell leukemia variant: recent view on diagnosis, biology and treatment. Cancer Treat Rev. 2011;37(1):3–10. doi: 10.1016/j.ctrv.2010.05.003.

  8. Traverse-Glehen A, Baseggio L, Callet-Bauchu E, et al. Splenic red pulp lymphoma with numerous basophilic villous lymphocytes: a distinct clinicopathologic and molecular entity? Blood. 2008;111(4):2253–60. doi: 10.1182/blood-2007-07-098848.

  9. Хвастунова А.Н., Аль-Ради Л.С., Федянина О.С. и др. Особенности морфологии и иммунофенотипа опухолевых клеток лимфомы из клеток маргинальной зоны селезенки (исследование с помощью клеточного биочипа). Онкогематология. 2017;12(1):71–7. doi: 10.17650/1818-8346-2017-12-1-71-77.

    [Khvastunova AN, Al-Radi LS, Fedyanina OS, et al. Determination of morphology and immunophenotype of circulating lymphoma cells in patients with splenic marginal zone lymphoma using an anti-CD antibody microarray. Oncohematology. 2017;12(1):71–7. doi: 10.17650/1818-8346-2017-12-1-71-77. (In Russ)]

  10. Mott F. Observations on the brains of men and animals infected with various forms of trypanosomes. Preliminary note. Proc Royal Soc London B. 1905;76(509):235–42. doi: 10.1098/rspb.1905.0016.

  11. Jacob H, Lutcke A. Subakute sklerosierende leukoencephalitis unter dem initialbild einer akuten epidemischen encephalitis (akute parkinsonistische encephalitis) mit ausgepragter entwicklung von Maulbeerzellen und Russell-Korperchen. J Neurol Sci. 1971;12(2):137–53. doi: 10.1016/0022-510X(71)90045-1.

  12. Greenwood BM, Whittle HC. Cerebrospinal fluid IgM in patients with sleeping sickness. Lancet. 1973;302(7828):525–7. doi: 10.1016/s0140-6736(73)92348-9.

  13. Alanen A, Pira U, Lassila O, et al. Mott cells are plasma cells defective in immunoglobulin secretion. Eur J Immunol. 1985;15(3):235–42. doi: 10.1002/eji.1830150306.

  14. Posnett DN, Mouradian J, Mangraviti DJ, Wolf DJ. Mott cells in a patient with a lymphoproliferative disorder. Differentiation of a clone of B lymphocytes into Mott cells. Am J Med. 1984;77(1):125–30. doi: 10.1016/0002-9343(84)90446-7.

  15. El-Okda M, Hyeh Y, Xie SS, Hsu SM. Russell bodies consist of heterogeneous glycoproteins in B-cell lymphoma cells. Am J Clin Pathol. 1992;97(6):866–71. doi: 10.1093/ajcp/97.6.866.

  16. Kurihara K, Sakai H, Hashimoto N. Russell body-like inclusions in oral B-lymphomas. J Oral Pathol.1984;13(6):640–9. doi: 10.1111/j.1600-0714.1984.tb01466.x.

  17. Джулакян У.Л., Двирнык В.Н., Менделеева Л.П. Селезеночная В-клеточная лимфома из клеток маргинальной зоны с выраженной плазмоклеточной дифференцировкой: вариант опухоли из клеток Мотта? Онкогематология. 2015;10(4):34–7. doi: 10.17650/1818-8346-2015-10-4-34-37.

    [Dzhulakyan UL, Dvirnyk VN, Mendeleeva LP. Splenic B-cell marginal zone lymphoma with marked plasmocytic differentiation: tumor variant from Mott cells? Oncohematology. 2015;10(4):34–7. doi: 10.17650/1818-8346-2015-10-4-34-37. (In Russ)]

  18. Mossafa H, Malaure H, Maynadie M, et al. Persistent polyclonal B lymphocytosis with binucleated lymphocytes: a study of 25 cases. Br J Haematol. 1999;104(3):486–93. doi: 10.1046/j.1365-2141.1999.01200.x.